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American neuroscientists have discovered that light and sound stimulation can improve cognitive and memory impairments in mice, indicating the possibility of treating Alzheimer's disease.
The study, published Thursday in the journal Cell, showed that a combination of visual and auditory stimulation to induce brain waves called gamma oscillations could eliminate amyloid plaques in the brain of mice, including essential areas to learning and memory.
Previous studies have shown that patients with Alzheimer's disease have impaired their gamma-frequency oscillations. The oscillations range from 25 to 80 Hz and would contribute to brain functions such as attention, perception and memory.
Researchers at the Mbadachusetts Institute of Technology and the Georgia Institute of Technology found that flickering light at 40 Hz, combined with auditory stimulation, could reduce plaques in the prefrontal cortex where higher cognitive functions were developing.
The treatment has also boosted the activity of immune cells known as microglia, which are superimposed around the plates.
In an ongoing study, researchers are badyzing the incidence of gamma oscillations on certain types of brain cells and have performed preliminary safety tests of this type of stimulation in healthy subjects.
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