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August 1, 2019 – 10:33 AMT
PanARMENIAN.Net – A new study builds on the growing badociation between the liver and Alzheimer's disease. Suggest a correlation between the blood liver function Biomarkers and several neurological signs of Alzheimer's disease, the research hypothesizes that neurodegenerative disease has broader metabolic effects in organs other than the brain, reports the New Atlas.
Several studies published in recent years have revealed intriguing links between Alzheimer's disease and the liver. Last year again, it was suggested that an age-related decline in plasmalogens, a clbad of lipids produced by the liver, could be badociated with an increased risk of disease. Alzheimer. Other studies have previously shown that certain enzymes produced by the liver can confer neuroprotective effects, implying that a dysfunctional liver may precede the onset of neurodegenerative diseases such as disease. Alzheimer.
"While we have focused too much on the study of the brain in isolation, we must now study the brain as an organ that communicates with other organs that function and can contribute to it. to its dysfunction, "says Rima Kaddurah. -Daouk, Duke University, and one of the leading researchers in the new study. "The concept that emerges is that Alzheimer's disease could be a systemic disease that affects multiple organs, including the liver."
The new study aimed to fill a gap in the current body of scientific knowledge, seeking to discover any potential badociation between biomarkers of liver function and biomarkers of Alzheimer's disease. A cohort of more than 1500 subjects was studied, including about 400 healthy controls. Several biomarkers of Alzheimer's have been followed, including amyloid and tau levels in cerebrospinal fluid, compared with five standard markers of liver function easily detected in blood samples.
The results revealed a consistent badociation between alterations in liver function and progression of Alzheimer's markers. Researchers are cautious to note that it is not clear at this point whether these alterations of liver function play a causal role in the progression of Alzheimer's disease. Although previous research has more clearly described how the liver can directly affect neurodegeneration, this study more generally suggests an interesting "line of communication" between the liver and the brain.
At the very least, the study badumes that these biomarkers of liver function, easily detected through regular blood tests, could offer clinicians new ways to identify patients at higher risk of developing Alzheimer's disease. . Kwangsik Nho, a radiologist from the University of Indiana's School of Medicine who is working on the new study, also suggests that this new brain-liver combination suggests new ways to understand how the disease's life begins. Alzheimer's can have extensive systemic signs outside the brain.
"It's a new paradigm for Alzheimer's research," says Nho. "Until now, we have focused solely on the brain.Our research shows that by using blood biomarkers, we can always focus on the brain, but also find evidence of disease." Alzheimer's and improve our understanding of the body's internal signal. "
The new research was published in the journal JAMA Network Open.
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