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New study suggests reducing insulin production in the body could reduce the risk of pancreatic cancer in people with type 2 diabetes.
Canadian scientists from the University of British Columbia claim that the relationship between insulin and cancer is still not clear, but point out that lifestyle changes aimed at lowering levels Fasting insulin could be helpful for cancer prevention.
The study involved five years of experiments to find out more about high levels of insulin production (hyperinsulinemia) – a hallmark of obesity and type 2 diabetes – and of the risk of cancer.
In mice whose insulin gene dosage was reduced, a modest reduction in fasting insulin was badociated with a 50% reduction in the risk of pancreatic cancer. The results were obtained in the absence of a change in fasting glucose.
"While this work focuses on pancreatic cancer, where the known badociation between hyperinsulinemia and cancer is highest, we believe that it could be applied to others." cancers badociated with hyperinsulinemia, "said author of the study, James D. Johnson, of the University of British Columbia. is also part of the Institute of Personalized Therapeutic Nutrition.
The researchers concluded: "Together, our data indicate that endogenous diseases [produced by the body] The hypersecretion of insulin contributes decisively to the development of pancreatic cancer. "
The results indicate that taking steps to reduce insulin production could help obese people and type 2 diabetes reduce the risk of cancer. This can be done by making positive changes in lifestyle, such as eating fewer carbohydrates, sugar and processed foods.
"Nevertheless, the causal relationship between hyperinsulinemia and cancer remains to be determined directly," the researchers added.
The review was published online in Cell Metabolism.
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