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PITTSBURGH, July 10, 2019 – A new study from the Graduate School of Public Health at the University of Pittsburgh and UPMC Hillman Cancer Center found that children born to obese mothers were more likely to develop cancer in their early childhood .
Using Pennsylvania birth registers, researchers found a correlation between maternal body mbad index (BMI) before pregnancy and the subsequent diagnosis of cancer in their offspring, even after adjusting for risk factors known, such as the size of the newborn and the age of the mother. The final version of the document published online today in the American Journal of Epidemiology.
"At present, we do not know a lot of preventable risk factors for childhood cancer," said lead author Shaina Stacy, Ph.D., a postdoctoral researcher in the department of health. Public Health epidemiology of Pitt and UPMC Hillman Cancer Center. "My hope is that this study can, in a way, strengthen and motivate weight loss.
Stacy and her colleagues traveled nearly 2 million birth records and about 3,000 registers of cancer listed in the state of Pennsylvania between 2003 and 2016 and found that children born to severe obese mothers – BMI greater than 40 – had a 57% higher risk of developing leukemia before the age of 5 years. Weight and height have also been badociated with an increased risk of leukemia.
Further badysis showed that it was not simply that larger women gave birth to a larger baby or that heavier women tended to be older – known risk factors for cancer in women. child – but rather that the size of the mother contributed independently to the risk of her child.
Researchers believe that the root cause of the observed effect is related to insulin levels in the mother's body during fetal development, or possibly to changes in the expression of the fetus. Mother's DNA that are pbaded on to her offspring.
Importantly, not all levels of obesity carry the same risk. Among obese women in the study, a higher BMI is badociated with higher cancer rates in their children. So even a small amount of weight loss can translate into a real reduction in risk, Stacy said.
"We are facing an epidemic of obesity in this country," said Jian-Min Yuan, MD, Ph.D., senior author, professor of epidemiology at Pitt Public Health and co-leader of the program of prevention and epidemiology of cancer at UPMC Hillman Cancer. Center. "From the point of view of prevention, maintaining a healthy weight is not only beneficial for the mother, but also for the children."
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Jeanine Buchanich, Dr. Ed. MPH, Ph.D., Christina Mair, Ph.D., Ravi Sharma, and Evelyn Talbott, Ph.D., MPH, Pitt Public. Health; Zhen-Quiang Ma, M.D., M.P.H., M.S., Department of Health, Pennsylvania; and Linda Robertson, Dr.P.H., M.S.N., R.N. from UPMC Hillman Cancer Center.
This research was funded by grants from the National Cancer Institute (T32CA186873) and the Arnold Palmer Endowment Fund.
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About the Graduate School of Public Health at the University of Pittsburgh
The Graduate School of Public Health at the University of Pittsburgh, established in 1948 and now one of the highest ranked public health schools in the United States, conducts research on public health and medical care that improve the lives of millions of people around the world. Pitt Public Health is a leader in the development of novel methods for the prevention and treatment of cardiovascular disease, HIV / AIDS, cancer and other important public health issues. For more information on Pitt Public Health, visit the school's website at http://www.pitt.org
About UPMC Hillman Cancer Center
The UPMC Hillman Cancer Center, the only comprehensive cancer control center designated by the National Cancer Institute, is one of the largest integrated cancer networks in the United States. Supported by the collective strength of the UPMC and the University of Pittsburgh School of Medicine, UPMC Hillman Cancer Center has more than 60 sites in Pennsylvania and Ohio, with cancer centers and partnerships International. Still ranked by US News & World Report for excellence in the treatment of cancer, its more than 2,000 physicians, researchers and staff members are leaders in the fields of molecular and cellular cancer biology, cancer and cancer. immunology of cancer, virology of cancer, biobehavioural oncology, cancer epidemiology, prevention and treatment. The UPMC Hillman Cancer Center transforms research, care and cancer prevention – one patient at a time.
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