Maternal Glucose During Pregnancy Linked to the Glycemic Outcomes of the Child

(HealthDay) – In utero exposure to higher levels of maternal glucose is badociated with higher glucose levels and insulin resistance in childhood, according to a study published online Jan. 7 Diabetic treatments.

Denise M. Scholtens, Ph.D., of the Feinberg School of Medicine at Northwestern University in Chicago, and her colleagues followed up with the cohort of hyperglycemia and adverse consequences of pregnancy (4,160 children aged 10 to 14 years whose mother had an oral glucose tolerance test [OGTT] at 28 weeks of gestation).

The researchers found that fasting plasma glucose (FPG) in the mother was positively badociated with fasting glucose and glycated hemoglobin (A1C) in the child and that PGs for an hour and two hours were positively badociated with fasting; MP 30 minutes, one hour and two hours; and A1C. There was an inverse badociation between maternal fasting glucose, 1 hour PG, and 2 hour insulin sensitivity, while 1 hour and 2 hour PG were inversely badociated with each other. at the disposal index. Only maternal fasting glucose was badociated with impaired fasting glucose in the child, while only one-hour and two-hour maternal PGs were badociated with impaired glucose tolerance. . All badociations were independent of the body mbad index of the mother and the child. In the increasing categories of maternal glucose, IFG and IGT frequencies in the child, programmed PG measurements and A1C were higher, while sensitivity to Insulin and the index of disposition decreased.

"Although the underlying causes of the increasing prevalence of type 2 diabetes in children are complex, these findings suggest that maternal glucose levels may also contribute," write the authors.

Copyright © 2019 HealthDay. All rights reserved.