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A study published in the journal Diabetic treatments found that not following the usual bedtime and waking hours can increase the risk of obesity, high cholesterol and other metabolic disorders.
The increased variability in the duration and timing of sleep was badociated with a higher prevalence and incidence of metabolic abnormalities. Image credit: Wok & Apix.
"Our findings suggest that maintaining a regular sleep schedule has beneficial metabolic effects," said Dr. Susan Redline of Brigham and Women's Hospital.
"This message could enrich current strategies for the prevention of metabolic diseases, which are aimed primarily at promoting adequate sleep and other healthy lifestyles."
In this study, Dr. Redline and her colleague Dr. Tianyi Huang followed 2,003 men and women, aged 45 to 84, participating in the multi-ethnic atherosclerosis (MESA) study.
Participants were studied for an average of six years to determine badociations between sleep patterns and metabolic abnormalities.
To ensure objective measurement of sleep duration and quality, participants wore actigraph wristwatches to monitor sleep schedules for seven consecutive days. They also kept a sleep diary and answered standard questionnaires about sleep patterns and other lifestyle and health related factors.
Participants completed the follow-up of actigraphy between 2010 and 2013 and were followed until 2016 and 2017.
Individuals with more variable bedtime and sleep times had a higher prevalence of metabolic problems, and these badociations persisted after adjusting for average sleep duration.
This was also the case when they examined participants who developed metabolic disorders during the 6.3 years of follow-up.
The prospective results showed that variations in sleep duration and bedtime preceded the onset of metabolic dysfunction. This provides evidence to support a causal link between irregular sleep and metabolic dysfunction.
Participants whose sleep duration varied more than one hour were more likely to be African-Americans, work schedules outside of the days, to smoke and to have a longer sleep duration short. They also had higher depressive symptoms, total caloric intake, and sleep apnea index.
Increased sleep duration or bedtime variability was strongly badociated with multiple metabolic and concurrent problems, such as low HDL cholesterol ("good" cholesterol) and waist circumference, high blood pressure , total triglycerides and fasting glucose.
"Many previous studies have shown the link between sleep deprivation and increased risk of obesity, diabetes and other metabolic disorders," said Dr. Huang, also from Brigham and Women's Hospital.
"But we did not know much about the effects of irregular sleep, of the great variability of duration and duration of sleep. Our research shows that, even taking into account the amount of sleep a person has and other lifestyle factors, a night / night difference of one hour at bedtime or the length of sleep multiplies adverse metabolic effects. "
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Tianyi Huang and Susan Redline. Cross-sectional and prospective badociations of sleep regularity badessed by actigraphy with metabolic abnormalities: The multi-ethnic study of atherosclerosis. Diabetic treatments, published online June 5, 2019; doi: 10.2337 / dc19-0596
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