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April 21, 2021
1 min read
Source / Disclosures
Disclosures: MacDonald reports receiving funding from the French Federation of Cardiology. Please see the study for relevant financial information from all other authors.
Women with migraine had an increased risk of hypertension after menopause, but there was no significant difference between migraine with and without aura, according to a longitudinal cohort study launched in 1990.
“Migraine, in particular migraine with aura, has been identified as a risk factor for cardiovascular disease”, Conor James MacDonald, PhD, of the French Institute for Health and Medical Research and the Center for Research in Epidemiology and Population Health at the Gustave Roussy Institute in Villejuif, France, and colleagues wrote in Neurology. “It is less clear how a history of migraine might be associated with postmenopausal hypertension.”
MacDonald and colleagues conducted a prospective longitudinal cohort study of 56,202 women aged 40 to 65 at baseline who did not have hypertension or CVD at the onset of menopause (mean age at menopause, 50, 4 years). Participants completed questionnaires every 2 to 3 years from 1990 to 2014 and reported whether they had migraine or high blood pressure. The researchers used insurance data to check for migraine and hypertension. They performed a secondary analysis evaluating migraine with vs. without aura; data collection for this analysis began in 2011.
Of 12,501 cases of incident hypertension, 3,100 occurred in women with migraine and 9,401 in women without migraine. Postmenopausal women with migraine had an increased risk of hypertension (HR = 1.29; 95% CI, 1.24-1.35); the researchers wrote that this association persisted when monitoring migraine medications and other post-hoc sensitivity analyzes.
According to the researchers, the association between migraine and hypertension was similar in women with migraine who did and did not report an aura, but there was a “slightly stronger” association in women who did. had previously used menopausal hormone therapy (HR = 1.34; 95% CI, 1.27-1.41) compared to those who had never used menopausal hormone therapy (HR = 1.19; 95% CI %, 1.11-1.28).
“Hypertension and migraine are two common disorders in women, but relatively few longitudinal cohort studies have been conducted to understand this relationship, and none in postmenopausal women only,” the researchers wrote. “In this longitudinal cohort study, we confirmed previous observations that migraine is associated with an increased risk of incident hypertension in postmenopausal women.”
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