Molecular action that allows coriander to effectively delay some undiscovered crises

Herbs, including coriander, have long been used as anticonvulsants by traditional medicine. Until now, many mechanisms underlying the functioning of herbs remained unknown. In a new study, researchers have discovered the molecular action that allows coriander to effectively delay some epileptic seizures common in epilepsy and other diseases.

The study, published in FASEB Journal, explains the molecular action of coriander (Coriandrum sativum) as a very powerful KCNQ channel activator. This new understanding could lead to therapeutic improvements and the development of more effective drugs.

We discovered that coriander, used as a traditional anticonvulsant drug, activates a clbad of potbadium channels in the brain to reduce epileptic activity. Specifically, we discovered that a component of coriander, called dodecenal, binds to a specific part of the potbadium channels to open them, thereby reducing cell excitability. This specific finding is important because it can lead to more efficient use of coriander as an anticonvulsant or to dodecenal modifications in order to develop safer and more effective anticonvulsant drugs. "

Geoff Abbott, PhD, professor of physiology and biophysics at the UCI School of Medicine, principal investigator of the study

The researchers examined the metabolites of coriander leaves, revealing that a long-chain (E) -2-dodecenal-active fatty aldehyde – activates multiple potbadium channels, including the predominant neuronal isoform and the predominant cardiac isoform, responsible for the regulation of electrical activity in the brain. heart. It has also been found that this metabolite summarizes the anticonvulsant action of coriander, delaying certain chemically induced seizures. The results provide a molecular basis for the therapeutic actions of coriander and indicate that this ubiquitous culinary herb has a surprising influence on clinically important potbadium channels.

The documented use of botanical folk medicines dates back as far as recorded human history. DNA evidence, dating back 48,000 years, suggests the consumption of plants for medicinal purposes by Homo Neanderthalensis. Archaeological evidence dating back 800,000 years suggests non-food use of plants by Homo erectus or similar species. Currently, evidence of the efficacy of traditional botanical medicines ranges from anecdotal to clinical trials. In many cases, these "drugs" are currently consumed, often on a large scale, as food or flavoring products. Coriander, known as coriander in the UK, is an example. Coriander has been consumed by humans for at least 8000 years. It was found in the tomb of Tutankhamun and allegedly cultivated by the ancient Egyptians.

"In addition to its anticonvulsant properties, coriander has also reported anticancer, anti-inflammatory, anti-fungal, antibacterial, cardioprotective, gastric and badgesic effects," Abbott said. "And the best part is that it's good!"