[ad_1]
The incidence of colorectal cancer in adults under 50 has increased in the United States since 1970. A new study published online early in CANCER, a peer-reviewed journal of the American Cancer Society, found that the proportion of adults diagnosed with colorectal cancer in the under-50s in the United States had continued to decline. increase over the last decade and that younger adults were diagnosed with more advanced disease.
To determine recent trends in colorectal cancer rates, Boone Goodgame, MD, of the University of Texas at Austin, and his colleagues reviewed registry information from the National Cancer Database, which includes over 70% new cases of cancer in the United States. From 2004 to 2015 (the most recent year included in the database), 130,165 patients under the age of 50 and 1,055,598 patients over the age of 50 were diagnosed with colorectal cancer.
Among the main discoveries:
- The proportion of patients diagnosed with colorectal cancer aged less than 50 years increased from 10% in 2004 to 12.2% in 2015.
- The proportion of onset youthful illness was higher in Afro-American and Hispanic populations than non-Hispanic whites from 2004 to 2015.
- Fifty-one percent of younger adults were diagnosed with advanced stage III / IV cancer compared with 40% of those over 50 years of age.
- Diagnoses in men under 50 increased only among non-Hispanic whites, while among women, both Hispanic and non-Hispanic whites experienced an increase in younger diagnoses over time.
- Diagnostic rates of colorectal cancer in young adults have increased over time, regardless of income level. The highest proportion of diagnoses of young adults has occurred in the upper income category.
- The proportion of colorectal cancers diagnosed in younger people has increased in urban areas, but not in rural areas.
"Several studies have shown that colorectal cancer rates in young adults have been slowly increasing in the United States since the 1970s, but for practicing physicians, it appears that we are seeing more and more young people with colorectal cancer now even 10 years ago, there is, "said Dr. Goodgame. "Until last year, the guidelines recommended screening for colon cancer from the age of 50. Today, many guidelines recommend screening at age 45, but most doctors and patients do not seem to follow these recommendations. "
Dr. Goodgame noted that the cause of increased rates of colorectal cancer in younger patients is unclear, but recent research suggests that it could be more likely than not. 39; a combination of increased body weight and changes in gastrointestinal bacteria.
In an accompanying editorial, Chyke Doubeni, MD, MPH, of the University of Pennsylvania, stressed the need for additional research. "Since the number of cases of colorectal cancer of hereditary origin is much higher in younger people, it is not known whether the detection of sporadic cases in a group with such a low disease rate can result in a favorable balance. between damages and benefits, "he wrote. "It is therefore imperative that the various hypotheses for increasing the incidence of colorectal cancer in people under 50 years of age be rigorously tested to determine whether the change in the current age of screening in people with no increased family risk are the most appropriate public health response. "
The American Cancer Society's Colorectal Cancer Screening Guideline recommends that adults aged 45 years and over at average risk be screened regularly, either by colonoscopy or by alternative methods, such as fecal immunochemical tests. and occult blood tests in the stool.
###
This research was funded by the National Cancer Institute via U01CA174706 and U01CA142565 and by the Texas Cancer Research and Prevention Institute via RR160005.
Additional information
NOTE: The information contained in this release is protected by copyright. Please include the newspaper badignment in all covers. A free summary of this article will be available in the cancer newsroom when it is published online. For more information or to get a PDF of any study, please contact:
Penny Smith +44 (0) 1243 770448 (UK)
[email protected]
Follow us on twitter @WileyNews
Complete quotes:
"Recent trends in age at the time of diagnosis of colorectal cancer in the US National Cancer Database, 2004 – 2015." John Virostko, Anna Capbado, Thomas E. Yankeelov and Boone Goodgame. CANCER; Posted online: July 22, 2019 (DOI: 10.1002 / cncr.32347).
URL at the time of publication: http: // doi.
"Early-onset colorectal cancer: what reported statistics can and can not tell us, and their implications." Chyke A. Doubeni. CANCER; Posted online: July 22, 2019 (DOI: 10.1002 / cncr.32346).
URL at the time of publication: http: // doi.
Author contact: Boone Goodgame, MD, University of Texas at Austin, [email protected]
About the journal
CANCER is a peer-reviewed publication of the American Cancer Society integrating scientific information from global sources for all oncology specialties. The goal of CANCER is an interdisciplinary forum for the exchange of information between oncology disciplines concerned with the etiology, evolution and treatment of cancer in humans. CANCER is published on behalf of the American Cancer Society by Wiley and is available online.
Follow us on twitter @JournalCancer
About Wiley
Wiley propels the world forward with research and education. Through publishing, platforms and services, we help students, researchers, universities and businesses achieve their goals in a changing world. For more than 200 years, we have been delivering consistent performance to all of our stakeholders. The company's website is accessible at http: // www.
Warning: AAAS and EurekAlert! are not responsible for the accuracy of the news releases published on EurekAlert! contributing institutions or for the use of any information via the EurekAlert system.
[ad_2]
Source link
