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A newly identified genetic mutation in a drug-resistant fungus can help fight antimicrobial resistance.
American and British researchers have discovered a new form of resistance to triazole, a drug used in the treatment of invasive aspergillosis, a disease caused by airborne fungi spores.
Professor Jarrod Fortwendel of the University of Tennessee said, "As for bacteria, resistance to antifungal medications is a real challenge for medicine.
"Understanding how the fungus becomes resistant to drugs is important for designing therapeutic changes aimed at overcoming aspergillosis."
Invasive aspergillosis is caused by breathing small spores of the airborne mushroom. Aspergillus fumigatus. These spores can cause problems in a weakened immune system, following an organ transplant or lung disorders such as asthma or cystic fibrosis. Aspergillosis is responsible for more than 200,000 life-threatening infections each year.
Although resistance to the clbad of triazole antifungals for the treatment of invasive aspergillosis remains unexplained, the findings could help form an effective approach to combating antimicrobial resistance.
Professor Dave Rogers, also in Tennessee, added, "It is very important that research continues and we learn more about why this event is happening and how we can deal with it in the future. "
The university teams involved in the research are based in Tennessee, Texas and Swansea in the United Kingdom. They are working on a five-year, $ 2 million collaboration, funded by the US National Institutes of Health.
They detailed the mutations found in triazole-resistant isolates in the American Microbiology Society mbio.
700,000 deaths a year worldwide due to drug-resistant infection: Dr. Peter Jackson speaks on antimicrobial resistance in Innovations 2018 laboratory
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