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Across the planet, 422 million people have diabetes. For the uninitiated, diabetes is a chronic metabolic disease characterized by high levels of glucose in the blood, or so-called blood sugar. This can lead to serious health problems, such as damage to the heart, blood vessels, eyes, kidneys and nerves.
SEE ALSO: A NEW TWO-HEAD TREATMENT AGAINST DIABETES AND OBESITY
However, diabetes is also badociated with a loss of muscle mbad. Under the guidance of Professor Wataru Ogawa of the Graduate School of Medicine at Kobe University, researchers may have been able to better understand the causes of this muscular atrophy phenomenon when blood glucose levels are high.
Diabetes and muscle loss
In addition to looking good, muscle mbad plays a vital role in your overall health, protecting your organs, stabilizing your metabolism and even prolonging your life. More importantly, the proper amount of muscle mbad can help you age gracefully, allowing your body to maintain certain physical tasks.
Understanding the correlation between diabetes and muscle loss could help inform people living with diabetes to stay healthier. According to the Kobe study, WWP1 and KLF15 proteins are at the origin of muscle atrophy.
Diabetes mellitus is a disease caused by insufficient action of the hormone insulin. Think of insulin as a regulator of your blood glucose, making sure your blood glucose is not too high.
However, insulin plays another role in promoting cell growth and proliferation. It was originally believed that this lack of growth was at the root of a decline in skeletal muscle mbad. Professor Ogawa begs to differ.
Professor Ogawa found that, in diabetic mice, muscle atrophy was attributed to the protein mentioned above, KLF15. High blood glucose slows the degradation of KLF15 protein. The WWP1 protein also accelerates this process by contributing to the slow degradation of KLF15.
This study is the first for those studying diabetes and its relationship to muscle loss. Although there is currently no viable medical treatment to prevent the loss of muscle mbad, this new vision could serve as a framework for future drugs.
As mentioned in the study, "If we develop a drug that enhances the function of WWP1 or weakens the function of KLF15, it would lead to a revolutionary new treatment."
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