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ARLINGTON, VA., March 25, 2019 / PRNewswire / – It may be possible to reduce the high risk of preterm birth in African-American women with certain immune and bacterial factors in the cervical and badl microbiome that seem to modulate this risk , according to new research published in Nature Communications. March of Dimes, the leading non-profit organization for maternal and newborn health, sponsored research at its premature University of Pennsylvania Perelman School of Medicine that helped lay the foundation for these newly published discoveries.
"If this study is confirmed, it could mean that a combination of supplementation of immune and bacterial factors could help overcome troubling racial inequalities during premature birth, in which African-American mothers and babies bear a greater burden." heavy, "said Kelle H. Moley, MD, Scientific Director of the March of Dimes. "We hope that this method of diagnosis and moderation of the microbiome to create a protective effect can become a new treatment for African-American women in the immediate future."
The March of Dimes comments came in response to the Perelman School of Medicine's new study at the University of Pennsylvania and the University of Maryland School of Medicine The discovery of seven types of bacteria and some immune factors in a woman's bad and cervix may be responsible for increasing the risk of, or protection from, spontaneous premature birth. The authors suggest that this information could help physicians better predict premature births, especially for African-American women in early pregnancy.
Today's release follows other mechanistic studies on the badl microbiome and prematurity conducted at the March of Dimes Premature Research Center at University of Pennsylvania Perelman School of Medicine, where the main author Michal Elovitz, MD, professor of obstetrics and gynecology at Penn Medicine, is also a co-investigator.
March of Dimes, the leading nonprofit organization for the health of mothers and babies, is pleased to support the work of the March of Dimes Premature Research Center at University of Pennsylvaniaincluding sponsoring research that laid the groundwork for these latest discoveries, "said Dr. Moley.
The presence or absence of certain bacteria in the microbiome of the cervix and bad – the community of organisms such as bacteria and viruses that normally inhabit the body – is known to affect the risk of premature labor. Some bacteria are badociated with significantly higher premature birth rate in African-American women United States.
The rate of prematurity (defined as birth before 37 weeks of pregnancy) in black women United States is 49% higher than the rate of all other women. More than 20% of premature babies are born to black women, or 1 in 5 babies in the United States. Premature birth and its complications are the leading cause of death in the first year of life United Statesand the leading cause of death among children under 5 in the world.
"The cervico-badl microbiota and the local immune response modulate the risk of spontaneous premature labor" in Michal A. Elovitz, Jacques Ravelet al. appeared in the March 21st problem of Nature Communications. The study was funded by the National Institute of Nursing Research of the National Institutes of Health.
The March of Dimes leads the fight for the health of all mothers and babies. We support research, run programs, and provide education and advocacy so that every baby can get the best start possible. Building on a successful 80-year legacy of influence and innovation, we empower every mother and every family. Visit marchofdimes.org or nacersano.org for more information. Visit shareyourstory.org for comfort and support. Find us on Facebook and follow us on Instagram and Twitter.
SOURCE March of Dimes
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