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A commonly used drug, fluconazole, used to treat badl yeast infections, is linked to higher rates of miscarriage if used during pregnancy, according to a new study published in the Canadian Medical Association Journal (CMAJ) .
Although topical treatments are first-line for pregnant women with fungal infections, oral fluconazole is often used during pregnancy.
The researchers examined data on 441,949 pregnancies in the Quebec pregnancy cohort between 1998 and 2015, making the link with the completed prescriptions listed in the Quebec Drug Insurance Database. They found that taking oral fluconazole was linked to adverse effects.
"Our study shows that taking any dose of oral fluconazole during pregnancy may be badociated with an increased risk of miscarriage," said Dr. Anick Bérard of the Université de Montréal. "Taking higher doses of fluconazole greater than 150 mg in early pregnancy may be linked to an increased risk of cardiac malformation in the newborn."
The study is compatible with other studies, although additional research is needed because the study sizes are still small.
In a related commentary, Drs. Vanessa Paquette and Chelsea Elwood, of the British Columbia Women's Hospital and Health Center in Vancouver, British Columbia, write: "The study emphasizes safe prescribing practices during pregnancy, including confirmation of pregnancy. correct diagnosis during pregnancy at the lowest appropriate doses. "
The document entitled "Associations between Low and High-dose Oral Fluconazole and the Consequences of Pregnancy: 3 Nested Case-control Studies" was published on 19 February 2019.
Source: Journal of the Canadian Medical Association
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