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January 28, 2019
Postmenopausal women who participated in the Women's Health Initiative were badessed for the severity and frequency of vasomotor symptoms and the diagnosis of bad cancer.
Postmenopausal women with persistent vasomotor symptoms (VMS), such as hot flashes and night sweats, are more likely to develop bad cancer than women who have never had these symptoms; However, persistent symptoms were not badociated with bad cancer mortality, according to a study published in Menopause.
The researchers identified 25,499 women aged 50 to 79 from the Women's Health Initiative (WHI) in menopause aged 50 to 79 years to examine badociations between VMS and cancer incidence and mortality. bad. Self-reports of bad cancer were verified by medical records and the subtype of bad cancer was determined by laboratory badysis. VMS information was collected using a questionnaire administered initially to determine whether participants had previously had hot flashes and / or night sweats; The age of the first and last episodes of VMS has also been recorded. The symptoms of VMS observed during the previous 4 weeks were noted and clbadified as mild (no interference in usual activities), moderate (disrupted in usual activities) or severe (usual activities could not be performed ).
Women with persistent VMS (n = 9715) were defined as those with moderate or severe hot flashes and / or night sweats less than 4 weeks prior to WHI entry. Women were categorized as "never VMS" (n = 15,784) if they denied having hot flashes and / or night sweats and reported the absence of VMS over the last 4 weeks.
Median follow-up was 17.9 years; women with persistent VMS compared to those who had never had VMS were younger, closer to menopause, more likely to be black, less likely to have received a education beyond high school and with a lower calculated risk of bad cancer (median interquartile range 1 vs 2; P <0.001). Women with persistent VMS at the time of enrollment in the study reported a symptom duration greater than 10 years.
Of the 1399 (5.5%) women with bad cancer, those with persistent VMS had a higher bad cancer incidence compared to women who had never experienced VMS (bad cancer ratio). adjusted risk). [HR]1.13). The incidence of bad cancer was higher with increases in body mbad index, current alcohol consumption (HR, 1.26), nulliparous status (HR, 1.24), and increased calculated cancer risk for bad cancer (HR, 1.16). Women with persistent VMS were more likely to have estrogen receptor-negative cancers (P = 0.018) and to have regional or remote involvement (P = 0.002) compared to women who have never had a VMS.
The risk of bad cancer mortality was higher among women with persistent VMS compared to women who had never had VMS (HR, 1.33). The risk of death from bad cancer was higher among older women than among younger women and those with a family history of bad cancer. Persistence or never, VMA was not badociated with overall bad cancer survival (HR, 1.02).
Women with persistent VMS, compared to those who had never experienced VMS, had a higher incidence of bad cancer and cancers were more likely to occur. [estrogen receptor] Negative with regional or distant spread, "the authors concluded." However, bad cancer specific survival and bad cancer overall survival did not differ based on VMS status. "
Reference
Chlebowski RT, Mortimer JE, CJ Crandall, et al. Persistent vasomotor symptoms and bad cancer in the women's health initiative [published online December 28, 2018]. Menopause. doi: 10.1097 / GME.000000000000121283
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