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The Qatar Biomedical Research Institute (QBRI), part of Hamad Bin Khalifa University (HBKU), recently collaborated on a study initiated by researchers at the University of Warwick in the United Kingdom to examine the impact of normal and high glucose levels on blood vessels.
The findings of the initial study, led by Dr. Naila Rabbani of Warwick Medical School, have been published in the journal "Scientific Reports" and could help identify new ways to prevent organ damage resulting from complications related to diabetes, according to a press release.
The research was conducted in collaboration with Professor Paul Thornalley, Director of the QBRI Diabetes Research Center, whose participation in the study began when he was Professor of Systems Biology at the University of Toronto. University of Warwick. The research team is currently working to further develop this research, including its application to the types of cells found in the kidneys, eyes and nerves of the arms and legs damaged by diabetes.
Professor Thornalley said, "It is an honor to have contributed to this pioneering research, which is making a vital contribution to the study of diabetes and to our evolving understanding of the disease. The research team also benefited from the inclusion of QBRI. Our diabetes research center is working to better understand diabetes through its innovative research, which is also an integral part of the study. "
According to researchers at the University of Warwick and QBRI, a mechanism in cells that line the blood vessels and help treat glucose in sugar, becomes uncontrolled in diabetic patients and could be related to the formation of blood clots and inflammation.
Dr Omar El-Agnaf, Executive Director of QBRI, said: "Faced with the growing prevalence of diabetes in Qatar and the region, the QBRI is committed to seeking new approaches to address this challenge. major health. We believe that our efforts can make great strides through strategic collaborations, and ongoing diabetes research with the University of Warwick will help us discover important information of global relevance. "
The researchers examined the impact of normal and elevated glucose levels on human endothelial cells, which form the lining of our blood vessels. By increasing the glucose concentration in the culture medium, the researchers modeled the effects of hyperglycemia on human endothelial cells – a condition in which an individual's blood glucose level is abnormally high and generally caused by diabetes.
Dr. Rabbani said, "The mechanisms of organ sensitivity to damage caused by high glucose levels in diabetes are still poorly understood and an urgent improvement in the treatment of diabetic complications is needed. Our study is a step forward in understanding these mechanisms.
"Our research has identified a likely key step, namely an increase in hexokinase-2 (HK2) in the initiation of the development of blood vessel damage in the hyperglycemia-related vascular complications of diabetes, such as kidney disease, retinal damage to the eyes and nerves. in the arms and legs, and the increased risk of heart disease – the leading cause of premature death in diabetes. It is important to note that we have shown how a new type of treatment, Glo1 inducer, can correct this problem and deserves to be taken into account in the search for better treatments for diabetes complications. "
The initial study confirmed that glucose metabolism in endothelial cells was increased at high glucose concentrations. They showed for the first time that this occurred because HK2 degrades more slowly in high glucose concentration and thus metabolizes more glucose than normal. An increase in glucose metabolism is the motor of metabolic dysfunction of endothelial cells in hyperglycemia pattern.
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