Regeneration cells | Science

summary

The ability to regenerate missing body parts is an important feature of many animals. An investigation of the cellular and molecular bases of regeneration using highly regenerative model organisms should identify the principles that explain how regeneration can take place and could explain why this regenerative capacity is limited in the region. 39; man. Hydra are freshwater cnidarians able to regenerate the whole body after amputation. On page 341 of this issue, Siebert et al. (1) report a cell-type transcriptome atlas of all major types of Hydra, generated by unicellular RNA sequencing (scRNA-seq). In another recent study, Aztekin et al. (2) used scRNA-seq to study Xenopus Regeneration of the tadpole's tail and identified a cell that regulates regeneration, which they call the Organizing Organ Regeneration (ROC). These sequencing approaches provide a wealth of molecular data that should allow future dissection of regenerative mechanisms.