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Category: Health published by Shameen Published on: May 24, 2019, 10:31 pm HIS Update: May 24, 2019, 10:31 pm HIS
Washington: In a new study, researchers have found that low levels of an circulating hormone called adropine predicted weight gain and metabolic dysregulation when consuming a high-sugar diet in a diet. nonhuman primate model.
According to the study published in the Journal of Biological Chemistry, these results will help pave the way for the development of new treatments for the management of metabolic diseases.
Obesity is a growing public health crisis, resulting in many serious risk factors, including cardiovascular disease and type 2 diabetes. While the number of overweight or obese people is now twice as high as People with a healthy weight, researchers are facing an urgent need to better understand how the body burns energy.
Andrew Butler, professor of pharmacology and physiology, discovered a few years ago the adropine, a peptide hormone. Butler's laboratory research suggests that adropine regulates the body's burning of glucose or fat.
They also found that young men with high levels of adropine had lower levels of body mbad index (BMI). In addition, some studies have indicated that low adropine is badociated with insulin resistance biomarkers.
In this study, Butler and his colleagues conducted studies at the California National Primate Research Center to explore the role of adropine in metabolic health.
They examined the plasma of 59 adult Rhesus macaques fed a high-sugar diet.
Overall, fructose consumption resulted in a 10% weight gain and an increase in fasting insulin level, indicating insulin resistance, which reduces the use of glucose. and high fasting triglyceride levels, which increases the risk of cardiovascular disease in humans.
Animals with low plasma concentrations of adropine developed a more severe metabolic syndrome.
Interestingly, the development of type 2 diabetes has been observed only in animals with low plasma concentrations of adropine. These animals also exhibited more pronounced dysregulation of glucose and lipid metabolism.
Fasting hyperglycemia was also restricted to animals with low circulating adropine, indicating glucose intolerance.
"Low-adropine monkeys may therefore not be equally oxidative of glucose, which explains their higher fat content because glucose is converted to fat instead of being used as a metabolic fuel," Butler said. .
"Last year, we reported that adropine appeared to be a product of the biological clock using mouse models and human cells in culture. We show in this article that ENHO gene expression is higher at daytime and lower at night in most primate tissues, "Butler said.
This is consistent with the idea that the expression of adropine is controlled via "clock-related" mechanisms.
Current findings suggest that adropine might link the biological clock to the rhythms of how the body uses sugar and fats as a metabolic fuel.
"At night, the body depends on energy stores stored as lipids in fat cells and during the day it depends more on carbohydrates from the diet," Butler said.
In this way, stimulating the expression of adropine by our internal clocks could help increase the use of glucose as a metabolic fuel during the day.
Source: ANI
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