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(Glasgow, June 8, 2019) Experts at the 52nd Annual Meeting of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition today present the results of a study showing higher levels of Advanced glycation end products (AGEs), found in abundance in junk food, are badociated with food allergy in children [1].
Researchers from the University "Federico II" of the University of Naples observed three groups of children aged 6 to 12 years (61 children in total): those with food allergies , those with respiratory allergies and healthy controls. The study found a significant correlation between subcutaneous levels of advanced glycation end products (AGEs) and junk food consumption, and that children with food allergies had subcutaneous levels of levels AGE higher than those of children with respiratory allergies or no allergies at all. . In addition, the research team found convincing evidence of the mechanism of action triggered by EFAs to determine food allergy.
EFAs are proteins or lipids that become glycated after exposure to sugars [2] and are present at high levels in junk food – sourced from sugars, processed foods, microwaved food and grilled meats or barbecued. It is already known that EFAs play a role in the development and progression of various oxidation-based diseases, including diabetes, atherosclerosis (where plaque accumulates in the arteries), and atherosclerosis. neurological disorders [3] but it's the first time that an badociation between AGE and food allergy has been found.
Although there is a lack of reliable statistics on the global prevalence of food allergies, it is increasingly evident that the incidence is increasing, especially in young children, and that the prevalence would reach 10% in some countries. [4,5,6]. Similarly, in recent decades, consumption of highly processed foods has increased significantly. [7] (which are known to contain higher levels of AGE), and highly processed foods would account for up to 50% of the total daily energy intake in European countries [8].
Commenting on the research, principal investigator Roberto Berni Canani said:
"To date, existing hypotheses and models of food allergy do not sufficiently explain the dramatic increase observed in recent years, so food EFAs may be the missing link." Our study confirms this hypothesis. We now need further research to confirm this, and if this link is confirmed, national governments will have greater incentives to strengthen public health interventions to limit junk food consumption among children. "
Isabel Proaño, Director of Policy and Communication of the European Federation of Allergy and Respiratory Disease Patient Associations (EFA) added:
"These new findings show that there are still many environmental and dietary issues that affect our health and well-being.Health care professionals and patients do not have all the important information to deal with an illness which significantly affects their quality of life and the lack of processing and labeling of industrialized food products does not help them.We call on the public health authorities to allow better prevention and better treatment of food allergies. "
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Notes to editors
For more information, to talk to Professor Roberto Berni Canani or an expert from ESPGHAN, please contact James M. Butcher at [email protected] or call +44 (0) 1444 811 099.
About the expert
Professor Roberto Berni Canani is Head of Allergy Program at the Department of Translational Medicine and Head of the Advanced Biotechnology Research Center ImmunoNutritionLab – CEINGE of Federico II University of Naples, Italy.
About ESPGHAN
The European Society for Pediatric Gastroenterology in Hepatology and Nutrition (ESPGHAN) is a multiprofessional organization whose aim is to promote children's health by paying particular attention to the gastrointestinal tract, liver and nutrition through the creation of knowledge , dissemination of scientific information. , promoting best practices in the provision of care and providing high quality education to pediatric gastroenterology, hepatology and nutrition professionals in Europe and beyond. For more information, visit http: // www.
About the 52nd Annual Meeting of ESPGHAN
The 52nd Annual Meeting of ESPGHAN will be held from 5 to 8 June 2019 at the SEC in Glasgow, United Kingdom.
Each year, the annual ESPGHAN congress attracts more than 4,600 experts and opinion leaders in the field of pediatric gastroenterology, hepatology and nutrition from 100 countries in Europe and five continents , making it the largest conference of its kind in the world.
The 52nd Annual Meeting of the European Society of Gastroenterology, Pediatric Hepatology and Nutrition in Glasgow is supported by the VisitScotland National Conference Application Fund and a grant from the Glasgow Convention Bureau. ESPGHAN would like to thank VisitScotland and the Glasgow Convention Bureau for their support.
For more information on the ESPGHAN congress, including to view the program, go to: https: /
References
1. Berni Canani, R, et al (2019). How junk food can contribute to the outbreak of food allergies: the potential role of advanced products of glycation. Presented at the 52nd Annual Meeting of ESPGHAN.
2. Goldin, Alison, et al. "Final products of advanced glycation: triggers the development of diabetic vascular injury." circulation 114.6 (2006): 597-605.
3. Vistoli, G., et al. "Advanced glycoxidation and lipoxidation end products (AGE and ALE): overview of their training mechanisms." Search for free radicals 471 (2013): 3-27.
4. Tang, Mimi LK and Raymond J. Mullins. "Food Allergy: Is Prevalence Increasing?" Journal of Internal Medicine 47.3 (2017): 256-261.
5. Loh, Wenyin and Mimi Tang. "The epidemiology of food allergy in the global context." International Journal of Environmental Research and Public Health 15.9 (2018): 2043.
6. Sicherer, Scott H. and Hugh A. Sampson. "Food Allergy: Review and Update of Epidemiology, Pathogenesis, Diagnosis, Prevention and Management." Journal of Allergy and Clinical Immunology 141.1 (2018): 41-58.
7. Fiolet, Thibault, et al. "Ultra-Transformed Food Consumption and Cancer Risk: Results from the NutriNet-Health Prospective Cohort." bmj 360 (2018): k322.
8. Slimani, N., et al. "Contribution of highly industrialized foods to nutrient intake and habits of middle-aged populations in the European prospective study on cancer and nutrition." European Journal of Clinical Nutrition 63.S4 (2009): S206.
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