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Scientists have discovered a way to block a protein that feeds tumors – calling it the "Achilles' heel" of cancer.
When the US team withdrew the ATF4 protein from cancer cells grown in a laboratory, it was "stressed" and went into self-destructive mode.
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Dr. Feven Tameire, lead author, said, "This shows us the potential impacts of targeting ATF4 in MYC-dependent tumors – which we are already studying.
"We are also working to confirm that this approach will not cause serious effects off target."
Professor Gerard Evan of Cancer Research UK's Cambridge Center said: "Myc is an important transcription factor, essential for most cancers, if not all cancers.
"However, it has proven difficult to target and there is currently no drug targeting Myc.
"This first research is promising. instead of targeting Myc directly, the authors found a new way to attack Myc through the back door.
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"However, many cancers express low levels of Myc, this approach may not be as effective in these cases.
"Nevertheless, it will be interesting to see if these results can be replicated in more types of cancer and if this approach can be used to guide the future treatment of Myc-dependent cancers."
The research, conducted at the University of Pennsylvania, is in the journal Nature Cell Biology.
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