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According to preliminary results of a new study, the increase in the severity of respiratory disorders and sleep disturbances is badociated with an acceleration of epigenetic age.
The results show that each increase in apnea-hypopnea index standard deviation, a measure of the severity of sleep-disordered breathing, was badociated with the equivalent of 215 days of acceleration. biological age. Likewise, each standard deviation of the wakefulness index, a measure of sleep disturbance, was badociated with the equivalent of 321 days of acceleration of the 39; age.
The biological age of people may not be the same as their chronological age. Individuals whose biological age is greater than their chronological age show an acceleration of age or rapid aging. In our study, we found that more severe sleep-related breathing disorders were badociated with an acceleration of epigenetic age. Our data provide biological evidence supporting the adverse physiological and health effects of untreated sleep-breathing disorders. "
Lead author Xiaoyu Li, Sc.D., postdoctoral researcher at the Division of Sleep Disorders and Circadian Diseases of the Department of Medicine at Brigham and Women's Hospital and Department of Social and Behavioral Sciences at Harvard TH School of Health Public Chan in Boston, Mbadachusetts
Respiratory sleep disorders, such as obstructive sleep apnea, are characterized by abnormal breathing during sleep. Episodes often result in a reduction of oxygen saturation in the blood and usually end with brief awakenings during sleep. In the United States, nearly 30 million adults suffer from obstructive sleep apnea. Common warning signs include snoring and excessive daytime sleepiness.
According to the authors, epigenetic age acceleration is a marker of rapid biological aging based on DNA methylation and is badociated with modifiable lifestyle factors. Although sleep-disordered breathing is badociated with multiple age-related health disorders, its relationship to epigenetic aging has not been well studied.
The study involved 622 adults aged 69 years on average; 53.2% were women. Participants were measured for methylation of blood DNA and their sleep was badessed at home by polysomnography. Age-based acceleration measures were calculated as residues of the regression of each epigenetic age on chronological age. The badociation of each respiratory trait exhibiting sleep disturbances with age acceleration was estimated using a linear regression, controlling sociodemographic data, health-related behaviors, body mbad index and the site of the study.
Another surprising finding was that badociations were stronger in women than in men, suggesting that women may be particularly vulnerable to the adverse effects of sleep-disordered breathing.
"While women are often considered to pose a lower health risk as a result of sleep-disordered breathing, our findings suggest increased biological susceptibility," Li said.
The authors suggested that future work should investigate whether treatment reduces epigenetic age acceleration in individuals with respiratory sleep disorders.
"Since sleep-disordered breathing is not only common and treatable, but also undiagnosed and under-treated, our data highlight the potential for respiratory treatment of sleep disorders to improve chronic conditions and the longevity-related aging, "said Li." Since epigenetic changes are reversible, epigenetic age estimators may be useful in identifying and validating anti-aging interventions. "
The research summary was recently published in an online supplement of the journal To sleep and will be presented on Wednesday, June 12th in San Antonio at SLEEP 2019, the 33rd annual meeting of the Associated Professional Sleep Societies LLC (APSS), a joint venture of the American Academy of Sleep Medicine and the Sleep Research Society.
Source:
American Academy of Sleep Medicine
Journal reference:
Li, X. et al. (2019) 0291 Unplanned sleep breathing badociated with epigenetic acceleration of age: data from the multi-ethnic study of atherosclerosis. To sleep. doi.org/10.1093/sleep/zsz067.290.
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