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Nowell replaces Joe Cokanasiga – the man of the Guinness match against Italy – on the right, while Henry Slade returns to the middle of the field.
At the front, Mark Wilson waved to Brad Shields while Ben Moon took the lead ahead of Ellis Genge in the front row.
Despite his exploits against the Azzurri, Cokanasiga retired completely from the group while Ben Te'o won the shirt n ° 23.
Ben Spencer is also in contention for a Guinness Six Nations first game when he is pulled off the bench, while England pursues a win against Auld Enemy on the other hand.
Ben Youngs will get his 85th selection for his country on Saturday and will become half of all records in England, ahead of Danny Care (Harlequins).
Eddie Jones said, "It's the last week of the tournament, it's exciting. It will be a fascinating finish to the championship with three teams that can win it and we play against one of our most traditional opponents in Scotland for the Calcutta Cup. We had a good preparation and the team will be in a very good condition to play against Scotland on Saturday.
Your England team to face @Scotlandteam Saturday in the #GuinnessSixNations
Full overview ➡ https://t.co/JhFUWgmbgF#ENGvSCO #CarryThemHome ? pic.twitter.com/sL014nXlRT
– England Rugby (@EnglandRugby) March 14, 2019
"Scotland is a difficult camp, they are always in your place, they play with a lot of enthusiasm and effort and have a lot of strings on their bow.
"Finn Russell is an outstanding player at age 10. He has a bit of a rhythm on the outside and we will have to really defend ourselves against them."
In Ben Youngs' record, he added, "It's a fantastic feat, it takes a lot of dedication and hard work, which he and his family will be really proud of. I'm sure he'll make the shirt very fair this Saturday. "
England leaving the XV to face Scotland (523 caps)
15 Elliot Daly (Wasps, 29 Caps)
14 Jack Nowell (Exeter Chiefs, 32 capitals)
13 Henry Slade (Exeter Chiefs, 21 capitals)
12 Manu Tuilagi (Leicester Tigers, 31 caps)
11 Jonny May (Leicester Tigers, 44 caps)
10 Owen Farrell (Saracens, 69 caps) (captain)
9 Ben Youngs (Leicester Tigers, 84 caps)
1 Ben Moon (Exeter Chiefs, 7 capitals)
2 Jamie George (Saracens, 36 caps)
3 Kyle Sinckler (Harlequins, 21 caps)
4 Joe Launchbury (Wasps, 57 Caps)
5 George Kruis (Saracens, 31 caps)
6 Mark Wilson (Newcastle Falcons, 12 capital letters)
7 Tom Curry (Sale Sharks, 9 Caps)
8 Billy Vunipola (Saracens, 40 Caps)
replacements (203 capsules)
16 Luke Cowan-Dickie (Exeter Chiefs, 10 capitals)
17 Ellis Genge (Leicester Tigers, 8 caps)
18 Dan Cole (Leicester Tigers, 84 caps)
19 Brad Shields (Wasps, 7 Caps)
20 Nathan Hughes (Wasps, 21 Caps)
Ben Spencer (Saracens, 2 caps)
22 George Ford (Leicester Tigers, 54 caps)
23 Ben Te'o (Worcester Warriors 17 caps)
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