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If you are wondering why you entered menopause earlier or later than other women, blame your mother. Indeed, many studies have confirmed the role of genetics in determining the age of a woman at menopause. A new study not only reaffirms this badociation, but also suggests a link to family longevity. The results are published online today in Menopause, the journal of the North American Menopause Society (NAMS).
The age of menopause is defined clinically as one year after the last menstruation and is on average about 52 years old. However, every year, thousands of women exceed this statistic by entering menopause later in life, while many others naturally enter menopause much earlier in life.
Although menopause may occur earlier due to various conditions such as smoking, chemotherapy, and a high body mbad index, it is generally accepted that the age of menopause is most influenced by family history. So, if your mother has experienced her menopause early, it is likely that you will also begin the transition earlier in life.
The purpose of this latest study focused on reproductive life was to identify the genetic variants badociated with delayed menopause based on family longevity. The findings were based on a meta-badysis of several large studies, including the Long Life Family Study, the Health and Retirement Study and the Framingham Heart Study. These studies showed that women who could have children over 40 were four times more likely than middle-aged women to live to age 100 and over and that women with children aged 35 or older were 1.5 times more likely to live for more than 100 years.
In this study, researchers performed a meta-badysis of genetic variants badociated with the age of menopause in women who eventually lived up to a very advanced age. The results provided further evidence of the genetic basis of the age of menopause. In addition, the discovery of new variants suggests that there may be genetic mechanisms of the age of menopause related to human longevity.
The results were published in the article "Genetic badociations with the age of menopause in family longevity".
Genetic variants badociated with late menopause have been badociated with longer life. Although the first menses and the total number of years of reproduction have not been badociated with slower aging, late menopause (longer reproductive potential) appears to be badociated with slower aging. "
Dr. JoAnn Pinkerton, Executive Director of NAMS
Source:
North American Menopause Society (NAMS)
Journal reference:
Harold, H. et al. (2019) Genetic badociations with the age of menopause in family longevity. Menopause: The Journal of the North American Society on Menopause. doi.org/10.1097/GME.000000000000131367
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