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Researchers at the University of Tampere have shown for the first time that brain embolisms of stroke patients contain DNA from oral pathogens. The article of research was published in the Journal of American Heart Association.
The researchers badyzed the thrombus aspirations, which radiologists neurointerventions took from 75 stroke patients as part of an emergency treatment. The samples were studied by duplicating bacterial DNA, showing that 79% of the aspirates contained DNA from bacteria from the teeth.
The study is part of a research project carried out at the University of Tampere, which has been studying the effects of a bacterial infection on the development of cardiovascular diseases for ten years. The research group has previously shown that the same odontogenic bacteria are present in the coronary artery stenosis of sudden death patients, thrombic aspirations and arterial blood from myocardial infarction patients, ruptured brain aneurysms and thrombotic aspirations of patients with arterial lower limb. vein thrombosis.
Thrombosis of the cerebral artery causes 87% of strokes. Most thrombi originate from carotid artery stenoses, from which they travel to block cerebral circulation.
The results showed that a large amount of streptococcal viridans DNA – a normal bacterium in the mouth – was found in brain thrombi compared to normal blood samples from the same patients. In the oral cavity, streptococci are harmless, but when they enter the circulation, they can notably cause heart valve infections. Streptococcal bacteria can bind directly to various platelet receptors, making the patient more vulnerable to blood clots.
Research shows that oral health and good dental hygiene are far more important to health than we previously knew, and that untreated dental infections can cause serious damage to health or even death.
Source:
University of Tampere
Journal reference:
PatrakkaOlli, et al. (2019) Oral bacterial signatures in cerebral thrombi of patients with acute ischemic stroke treated with thrombectomy. Journal of the American Heart Association. doi.org/10.1161/JAHA.119.012330.
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