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Uri Ashery and Dana Bar-on.
(photo credit: TEL AVIV UNIVERSITY)
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New research by a team of scientists at Tel Aviv University could significantly delay the progression of Parkinson's disease.
In particular, the researchers unveiled a new method for detecting the aggregation of the alpha-synuclein protein, characteristic of the neurodegenerative disorder that causes a disabling decrease in the motor and non-motor functions of a patient. Although treatments exist to alleviate some symptoms of the disease, there is no cure.
Nearly one million Americans and 10 million people worldwide are affected by the disease. People are dying with Parkinson's, no; as symptoms worsen, they can cause death incidents.
Parkinson's disease primarily affects dopamine-producing neurons in a specific area of the brain called substantia nigra. The symptoms usually develop slowly over the years. Thus, according to the TAU, by the time a patient is diagnosed with Parkinson's disease, 50% to 80% of these cells in this part of the brain are already dead, probably due to the development of a toxicity resulting from aggregation alpha-synuclein.
The researchers have developed a new method for tracking the early stages of aggregating alpha-synuclein using super-resolution microscopy and advanced badysis, explained Professor Uri Ashery, co – author of the study and director of the UAA Sagol School of Neuroscience at TAU, as well as George S Sage Faculty of Life Sciences.
"Together with our colleagues at Cambridge University, who developed a specific mouse model for Parkinson's disease, we were able to detect different stages of aggregation of this protein," he said in a statement. . "We correlated aggregation with the deteriorated loss of neuronal activity and deficits in the behavior of mice."
Dana Bar-On, co-author of the study, from the Sagol School of Neuroscience, said that by being able to detect the early stages of aggregation of alpha-synuclein , doctors will be able to monitor the effects of drugs on this aggregate.
By working with the Max Planck Institute in Göttingen and the Ludwig-Maximilians University in Munich, researchers were already able to demonstrate the effect of the drug anle138b on this aggregation of proteins. Similarly, they correlated these results with the normalization of Parkinson's phenotype in mice.
The research was published June 5 in the medical journal Acta Neuropathologica.
"This is an important step forward in the world of Parkinson's research," said Ashery, adding that "by detecting aggregates using minimally invasive methods in relatives of patients with Parkinson's disease we can provide early detection and intervention, as well as the ability to track the disease even before the symptoms are detected. "
And after? Bar-On said the team is currently working on implementing minimally invasive methods with Parkinson's patients.
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