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Toronto: Warn researchers, aging men with low testosterone and testosterone replacement therapy (TRT) are at increased risk of ischemic stroke or cardiac arrest, especially in the first two years d & # 39; use.
Published in the American Journal of Medicine, the results confirm the concerns expressed by many health organizations about the potential risks badociated with treatment.
"Our results show that the use of TRT was badociated with an increased risk of stroke, transient ischemic attack or cardiac arrest during the first two years of life. use, "said Christel Renoux of McGill University in Canada.
According to the researchers, there is little evidence on the long-term clinical benefits of TRT to effectively treat the slightly lower levels of endogenous testosterone levels in aging but healthy men.
"We strongly recommend that clinicians act with caution when considering prescribing a TRT and first discussing potential benefits and risks with patients," said Renoux.
The study badyzed a large database of electronic medical records of patients enrolled in primary care practices in the UK and trained a cohort of 15,401 men aged 45 and over with low testosterone levels (hypogonadism).
TRT users had a 21% higher risk of cardiovascular events than non-users, which corresponds to 128 additional events.
The increase in risk appears to be transient and decrease after two years of using TRT, which investigators attribute to a phenomenon called "exhaustion of sensitive subjects".
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