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Collagen powder is as effective in the management of skin biopsy wounds as primary closure with nonabsorbable sutures, according to a first study of its kind published in the Drug Diary in Dermatology by a team of medical researchers from George Washington University.
The team investigated the efficacy of topical collagen powder versus primary closure on the rate and quality of wound healing over the entire thickness through histopathological badysis of wound healing and a comparison of symptoms and early cosmetic results.
Collagen is better known as an essential structural component of many organs, including the skin, but it also plays a central role as a signaling molecule in the regulation of all phases of healing. Therefore, applied externally, collagen powder has great potential for healing and wound care because of its ability to stop bleeding, to recruit immune and skin cells essential for healing, as well as to prevent scarring. to stimulate the formation of new blood vessels and can be left in the wound without causing irritation or facilitating bacterial growth.
During normal wound healing, collagen acts as a scaffold for cell entry and growth in the wound bed and promotes deposition of new collagen. Although collagen has been used as an adjunct for wound healing, a good comparison with standard wound treatment is lacking. "
Adam Friedman, MD, Acting Director of the Department of Dermatology of the GW School of Medicine and Health Sciences, author of the study
The Friedman team administered two biopsies to eight volunteers and treated one wound with daily topical collagen powder and the other with a primary closure. The wounds were biopsied after four weeks for badysis and the subjects were asked to evaluate the itching, pain and treatment preferences throughout the process.
The researchers found that six of the eight collagen-treated wounds were completely healed four weeks after the initial wound and that all wounds were completely healed eight weeks after the second biopsy. Patients reported similar pain and itching for primary closure and collagen, most attributing itching to adhesive bandages rather than to the wound itself. The team concluded that, based on these findings, wounds treated with collagen powder healed at least as well as those treated with primary closure and that the powder could be applied safely for at least four weeks. .
"Given the cost and time required to place and remove sutures and the potential reimbursement of collagen, the use of a topical collagen powder for wounds due to perforation biopsy may be easier for the patient, not requiring additional visitation for removal of the suture and allowing equivalent healing or possibly better outcome, "said Friedman. "To move forward, we need to look deeper into the parameters of collagen use on wounds, including the duration of treatment and the size of the wound."
Source:
George Washington University
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