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Endocrine disrupting chemicals found in house dust promote the development of fat cells in a cellular model and could contribute to increased growth in the number of children in relation to their age, according to a study to be presented on Monday. March to ENDO 2019, annual meeting of the Endocrine Society in New Orleans, La.
"This is one of the first studies of the links between exposure to indoor chemical mixtures and the metabolic health of children living there," said principal investigator Christopher Kbadotis, Ph.D. ., from the Nicholas School of the Environment at Duke University. in Durham, NC
Previous research has shown that chemical exposures can promote the accumulation of triglycerides, a type of fat found in the blood, as well as increased obesity in animal models. Many observational studies have linked exposure to endocrine disrupting chemicals that can contribute to obesity and increased weight in humans.
In this study, Kbadotis and his colleagues studied the effect of chemical mixtures isolated from household dust. They collected 194 house dust samples from households in central North Carolina. They then extracted the chemicals from the laboratory dust. These extracts were tested for their ability to promote the development of fat cells in a cellular model.
They found that very low concentrations of dust extracts could promote the proliferation of precursor fat cells and the development of fat cells. According to the EPA, it is estimated that children consume between 60 and 100 milligrams of dust per day.
"We found that two-thirds of the dust extracts were able to promote the development of fat cells and half of those of the proliferation of precursor fat cells to 100 micrograms, about 1,000 times less than what children consume daily. "said Kbadotis.
The researchers then measured more than 100 different chemicals in the dust and examined the relationship between their concentrations and the extent of adipocyte development. They found that about 70 of the chemicals had a significant positive relationship with the development of fat-induced adipose cells, and about 40 were related to the development of precursor fat cells. "This suggests that mixtures of chemicals present in the indoor environment could be at the origin of these effects," said Kbadotis.
The researchers found that several chemicals were significantly high in the dust of homes of overweight or obese children. They continue to study these chemicals – some of which are present in common household products such as laundry detergents, household cleaners, paints and cosmetics – to determine which ones may be related to which ones they are used to. obesity.
This article has been republished from materials provided by the Endocrine Society. Note: Content may have changed for length and content. For more information, please contact the cited source.
Reference
Presented Monday, March 25 at the ENDO 2019 Conference, the annual meeting of the Endocrine Society in New Orleans, La.
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