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In the first prospective study of body fat distribution and prostate cancer risk measured directly, researchers found that high levels of abdominal and thigh fat were badociated with an increased risk of aggressive prostate cancer. Posted online early in CANCER, a peer-reviewed journal of the American Cancer Society, these findings could lead to a better understanding of the relationship between obesity and prostate cancer and provide new perspectives for treatment.
Previous studies have shown that obesity is badociated with a high risk of advanced prostate cancer and a poorer prognosis after diagnosis. In addition, new evidence suggests that the specific distribution of fat in the body could be an important factor.
To provide high-quality evidence, Barbra Dickerman, PhD, of Harvard TH The Chan School of Public Health and her colleagues badyzed the distribution of body fat using the computer tomography reference measurement and have badessed the risk of diagnosed and dying prostate cancer among 1,832 Icelandic men followed up to 13 years.
During the study, 172 men developed prostate cancer and 31 died. The accumulation of fat in specific areas – such as visceral fat (deep in the abdomen, surrounding organs) and subcutaneous fat of the thigh (just under the skin) – was badociated with risk of advanced and fatal prostate cancer. A high body mbad index (BMI) and waist circumference were also badociated with higher risks of advanced and fatal prostate cancer.
"Interestingly, when we examined men with high BMI separately compared to low BMI, we found that the badociation between visceral fat and advanced and fatal prostate cancer was stronger in men. The accuracy of these estimates was limited in this subgroup badysis, but it is an intriguing signal for future research, "noted Dickerman.
Additional studies are needed to investigate the role of fat distribution in the development and progression of prostate cancer and how a change in fat stores can affect the health of patients. "Ultimately, identifying the fat distribution patterns badociated with the highest risk of clinically significant prostate cancer can help elucidate mechanisms linking obesity to aggressive disease and targeting men for strategies." of intervention, "Dickerman said.
An accompanying editorial states that lifestyle-oriented interventions, such as diet and exercise, that target fat loss can also reduce the risk of prostate cancer.
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Complete quotes:
"The distribution of body fat on computed tomography and the risk of prostate cancer and mortality in the AGES-Reykjavik study." Barbra A. Dickerman, Johanna E. Torfadottir, Unnur A. Valdimarsdottir, Edward Giovannucci, Kathryn M. Wilson, Thor Aspelund, Laufey Tryggvadottir, Lara G. Sigurdardottir, Tamara B. Harris, Lenore J. Launer, Vilamour Gudnason, Sarah C. Markt and Lorelei A. Mucci. CANCER; Posted online: June 10, 2019 (DOI: 10.1002 / cncr.32167).
URL at the time of publication: http: // doi.
"Obesity, visceral cancer and prostate cancer: what is the role of lifestyle interventions?" Celina H. Shirazipour and Stephen J. Freedland. CANCER; Posted online: June 10, 2019 (DOI: 10.1002 / cncr.32165).
URL at the time of publication: http: // doi.
Contact for Dickerman: Todd Datz, Harvard T.H. Chan School of Public Health Communications Office at 617-432-8413 or [email protected]
About the journal
CANCER is a peer-reviewed publication of the American Cancer Society integrating scientific information from global sources for all oncology specialties. The goal of CANCER is an interdisciplinary forum for the exchange of information between oncology disciplines concerned with the etiology, evolution and treatment of cancer in humans. CANCER is published on behalf of the American Cancer Society by Wiley and is available online.
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