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Results of a genome-wide badociation study published in Genetic nature involved the metabo-psychiatric origins of anorexia nervosa, supporting the reconceptualization of both metabolic and psychiatric disorder.
"The metabolic abnormalities observed in patients with anorexia nervosa are most often attributed to starvation, but our study shows that metabolic differences may also contribute to the development of the disease", Gerome Breen, PhD, of the Institute of Psychiatry, Psychology and Neuroscience of King's College London, said in a press release. "In addition, our badyzes indicate that metabolic factors could play a role almost as important as purely psychiatric effects."
The researchers combined data from the Anorexia Nervosa Genetics Initiative and the Eating Disorders Task Force of the Consortium on Psychiatric Genomics and conducted a genome-wide badociation study of 16,992 cases. anorexia nervosa and 55,525 controls.
In total, eight significant loci were identified in the study. The results showed that the genetic architecture of anorexia nervosa reflected its clinical presentation, indicating significant genetic badociations with psychiatric disorders. According to the press release, the genetic underpinnings of anorexia overlap with obsessive-compulsive disorder, depression, anxiety, and schizophrenia.
There were also significant genetic correlations between anorexia and physical activity and metabolic (including glycemic), lipid, and anthropometric characteristics. The researchers reported that this was independent of the effects of common variants related to BMI.
The investigators also found metabolic factors badociated with anorexia nervosa more pronounced than in other psychiatric disorders, reporting significant negative polymorphisms of unique nucleotide polymorphisms with fat mbad, body fat, BMI, obesity, diabetes mellitus, and diabetes mellitus. type 2, insulin fasting, insulin resistance and leptin as well as a significant positive correlation with HDL cholesterol.
Janet Treasure
"Over time, the uncertainty surrounding anorexia nervosa remained unclear due to the mix of physical and psychiatric features. Our results confirm this duality and suggest that the integration of metabolic information could help clinicians develop better methods of treating eating disorders, Janet Treasure, PhD, of the research group on eating disorders at King's College London, said in the statement. – by Savannah Demko
Disclosures: Treasure Announces Fees for Participation in EAP Meeting and Royalties from Several Books of Routledge, Wiley and Oxford University Press. Please consult the study for the relevant financial information of all other authors.
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