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Hundreds of genes have recently been linked to depression, highlighting the origins of the disease and highlighting the types of personality potentially at risk.
The international study, covering more than two million people, is the largest of its kind. This could shed light on treatments for the disease, which affects one in five people in the UK and is the leading cause of disability in the world.
Scientists led by the University of Edinburgh studied information collected from three large sets of anonymized health data and DNA and identified 269 genes related to depression. They also used an innovative statistical method to identify common DNA sections in depressed people and those who engaged in lifestyle behaviors such as smoking.
The findings suggest that depression may be a determining factor driving some people to smoke, but further research is needed to explain why, the team said.
The results also show that neuroticism – a tendency to be worried or fearful – could lead people to become depressed, which could shed light on the personality factors that put them at risk. The statistical approach – known as Mendelian randomization – allows scientists to examine the impact of a condition on behavior, while excluding other influences such as Age or income.
Anonymized data, used with the consent of the donor, is held by UK Biobank, the 23andMe research and personal genetics company and the Psychiatry Genomics Consortium.
Experts say the study reflects the importance of data science in understanding mental health.
The study, published in Nature Neuroscience, was funded by the MRC and Wellcome.
Professor Andrew McIntosh, of the Center for Clinical Brain Sciences at the University of Edinburgh, who led the research, said: "These findings are further evidence that depression is partly due to our genetics.
"We hope the results will help us understand why some people are at greater risk of depression than others and how we could help people with depression and anxiety more effectively at home. ;to come up."
Sophie Dix, director of research at MQ, a mental health charity that did not participate in the research, said, "This study adds weight to the evidence that genes are one of the most risk of depression, which is also affected by life events, the social environment and trauma.The interest this represents for new technologies is evident in the development of personalized treatments – a welcome step, being Given the lack of innovation in identifying new approaches with depression and for the moment, the solutions available do not work for everyone.
"The power of this great genetic study lies in the fact that it can point to brain systems, which adds to our currently limited understanding in this area, improving our understanding of these systems and the way in which they work. "Social environment affects biological risk factors, we can start identifying new targets for treatments that could help millions of people affected by depression worldwide."
Depression study identifies genes that can trigger disease
indefinite indefinite et al. The meta-badysis of genome-wide depression identifies 102 independent variants and highlights the importance of prefrontal brain regions, Nature Neuroscience (2019). DOI: 10.1038 / s41593-018-0326-7
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