Track overall trends in the effectiveness of antibiotic therapy with the help of the drug resistance index

Antibiotic resistance represents a growing threat to global health, development and food security. Antibiotic resistance has been partly attributable to the use of antibiotics, which has increased by 66% since 2000. Despite global commitments to control antimicrobial resistance, it still does not exist. no effective system for monitoring progress at the global level. Evaluating and communicating the problem of antibiotic resistance to an unsuspecting public is a challenge because of the large number of bacterial species and antibiotics involved. In addition, a single bacterial species may be resistant to several clbades of antibiotics. Therefore, the potential threat to the health of patients varies depending on the genetic makeup and context of the pathogen.

To better understand the problem of resistance, researchers from the CDDEP have developed the Drug Resistance Index (DRI), which provides an overview of the effectiveness of antibiotic therapy by country. The DRI resembles stock indexes and combines measures of antibiotic consumption with resistance data to help compare overall resistance over time and across countries.

"The drug resistance index provides a useful and easy-to-understand metric that combines the use of antibiotics and resistance in a single digit," said the author of the report. study, Eili Klein. "This allows policymakers to understand the complex problem of resistance without going into the details of the diversity of different antibiotics and organisms, and to track the problem over time."

Using resistance data from the CDDEP ResistanceMap and data on the use of antibiotics extracted from the IQVIA MIDAS database, the researchers calculated the rates of exposure. IRC for 41 countries. Overall, the rates of CKD varied considerably from one country to another and ranged from a low of 8.1 in Sweden to a high of 71.6 in India.

High-income countries generally had lower CKD rates than low- and middle-income countries. The five countries with the least DLI were Sweden (8.1), Canada (9.7), Norway (16.5), Finland (20.2) and Denmark (24.1). ). The countries with the largest ANC, and hence the lowest relative effectiveness of antibiotic therapy, include India (71.6), Thailand (60.6), India (71.6), Thailand (60.6), India (71.6) and Thailand (60.6). Ecuador (60.3) and Venezuela (58.9). The ANRs for the other selected countries were 32.9 in Switzerland, 38.6 in Australia, 45.4 in the United Kingdom, 46.8 in Vietnam and 49.2 in Mexico.

"The DRIs show that low- and middle-income countries not only suffer from a heavier burden of disease, but also have less access to new, more effective drugs and, hence, a lower level of disease." effectiveness of antibiotics, "said Dr. Klein.

Changes in ANC were correlated with country income levels. In high-income countries, higher IDRs were due largely to differences in the use of antibiotics, with higher antibiotic consumption leading to increased resistance. In low- and middle-income countries, where the use of antibiotics per capita is generally lower than that of high-income countries, higher NRAs may reflect disparities in resistance surveillance and problems systems in health systems that increase the transmission of resistant pathogens.

The study titled "Tracking Global Trends in Efficacy of Antibiotic Therapy Using the Drug Resistance Index" was published on April 11, 2019 in the BMJ Global Health.

Provided by
Center for Disease Dynamics, Economics and Policy