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BEIJING, July 21 (Xinhua) – Researchers have progressed with non-invasive deep brain stimulation (UDBS) for the treatment of Parkinson's disease in model mice, according to a recent article in Research.
The cause of PD is mainly related to dysfunction of the deep cerebral nucleus and the neural circuit. The physical modulation of the deep core of the brain and its circuit is traditionally the standard method of treating brain diseases.
As a mechanical wave, ultrasound also has a high chance of intervening and treating brain diseases. The research team of the Shenzhen Advanced Technology Institutes of the Chinese Academy of Sciences demonstrated that UDBS stimulation of the subthalamic nucleus (STN) or globus pallidus (GP) could improve the motor behavior of MP model mice.
The data demonstrate that UDBS allows modulation of the neuronal activity of STN or GP and leads to neuroprotection in mice with PD, says the paper, potentially serving as a non-invasive strategy for clinical treatment of the MP.
Researchers have also developed a head-mounted portable ultrasonic transducer with a stimulation accuracy of up to one millimeter, which can focus precisely on the deep core of a model mouse.
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