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The device, which is applied to the truncated limb wound region, locally provides the hormone progesterone for 24 hours and helps initiate the tissue regeneration process and, finally, the partial regeneration of the foot.
Progesterone – which is known for its role in pregnancy – promotes the regeneration and regeneration of nerves, blood vessels and bones, as well as the positive response of the immune system to this regenerative process.
Although humans are not … frogs, this discovery helps to better understand the biological process of regenerating parts of the body in some animals and, most importantly, it may in the future pave the way for treatments similar for humans.
Many animals are able to regenerate cut parts of their bodies. Some, like some worms and "sea cucumbers", are able to regenerate their entire body when they are cut into pieces. Other species do this for individual parts, for example, lizards regenerate their cut tail, some crabs their calves and their deer horns.
Some frogs regenerate their legs, but only when they are still in a very young phase of their development rather than after adulthood. The new device was able to regenerate the hind legs in adult African frogs (Xenopus laevis), which had lost their physical capacity because of their age.
Researchers at the University of Taft, Mbadachusetts, led by neuroscientist Dr. Selia Herera-Rincon, have completed a relevant publication in the Cell Reports Cell Biology Journal.
The new device, made of silicone in a three-dimensional printer, contains a hydrogel of protein-bonding polymeric materials that is applied directly to the wound and allows the transfer of progesterone and other useful substances to the amputation site.
Experiments on experimental animals of larger mammals, starting with mice, are in progress.
SOURCE: RES
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