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Anti-drugs threaten humans and the number of community-resistant Staphylococcus aureus infections (CA-MRSA) has increased six-fold in 10 years, if the bacteria enters the lungs, the rate of mortality is 50%. In the past, the research community continued to sterilize but, before the drug is effective, it can not prevent the release of toxins by bacteria to destroy tissue, and there is a situation where "bacteria can not be saved ". The University of Hong Kong Medical School is the first to discover the non-antibiotic compound M21, which can inhibit the growth of many pathogenic factors at the same time. CA-MRSA looks like a "tiger" without teeth "and it is difficult to destroy the body. The team was waiting for the new drug to be released in the next five years.
Other reports: [court film + multi-image: le même jour aujourd'hui] 1925 torrential rain washed away the luxury home in the ring, took 75 lives, single landslide, the largest number of dead Staphylococcus aureus community-resistant 1258 case of infection , a sharp increase of 6-fold compared to 173 cases in 2007. Once infected, patients can cause skin ulceration, necrotizing pneumonia or meningitis, and the death rate of necrotizing pneumonia can reach 50%.
Currently, patients infected with CA-MRSA in Hong Kong can only be treated with antibiotics, in severe cases they must be completely sterilized, usually two or three days, during which the bacteria release toxins such as the lungs and the brain. Death.
The Faculty of Medicine at the University of Hong Kong badyzed more than 50,000 small molecule compounds and found that the M21 compound could effectively inhibit the CA-MRSA "control center" ClpP protease, so that it can not produce a lot of major causes. Viral strength factor. In other words, M21 can cause bacteria to lose the "lethal weapon" that attacks the human body. Gao Yicun, an badociate professor in the Department of Microbiology at the University of Hong Kong, explained that ClpP is a control center for the release of pathogenic factors such as lytic peptides that control soluble white blood cells and can destroy the red blood cells and small blood vessels. "Golden staphylococcal toxin" on the inner wall. M21 inhibits ClpP and prevents CA-MRSA from mbad-producing virulence, which is a "toothless tiger".
Gao Yicun continued, preliminary experiments in mice showed that infected mice received M21 treatment, survival rate reached 100% in one week, renal tissue was not infected and mice without treatment in less than a week. They died one after the other. The results of the study were published in the Proceedings of the National Academy of Sciences.
The Medical School of the University of Hong Kong discovered last year that the use of NP16 compounds to mitigate the viability of MRSA is more likely to occur. be eliminated by the body's immune system. He Boliang, director of the Center for Infectious Diseases and Infectious Diseases of the University of Hong Kong, said that M21 could inhibit toxins, prevent organ damage, and strive to recover patients. Immunity re-sterilization, as two compounds can be developed into drugs, in the future may be based on the patient's infection.
The team said that M21 still needed a structural transformation, and that it would undergo toxicity testing in animals and humans in the future, and that new drugs should be available in the next five years.
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