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In an episode of the first season when Raj, Leonard and Howard think of people who would replace Sheldon in their physics team, Raj says, "You know who is apparently very intelligent, it's the girl who has played TV Blossom . She got a doctorate in neuroscience or something. He was referring to the actor Mayim Bialik, who had joined the series in his third season as Sheldon's love interest, Amy Farah Fowler.
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