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By PTI
NEW YORK: Researchers have pushed locks of hair back onto damaged skin by waving cracks in the skin cells that form the hair roots.
Findings of researchers at New York University (NYU) In the United States, School of Medicine explains better why hair does not grow normally on injured skin.
The study, published in the journal Nature Communications, could contribute to the search for better drugs to restore hair growth.
Effect of distinct signaling pathways on the damaged skin of laboratory mice.
Experiments were conducted on cells called fibroblasts that secrete collagen, the structural protein most responsible for maintaining the shape and strength of skin and hair.
channel used by cells to communicate with each other.
It is known that this pathway is very active during the early stages of human growth in the uterus, when hair follicles form, but is another researchers explained that this may explain why follicles hair does not grow in the skin after an injury or surgery.
"Our results show that stimulation of fibroblasts by the sonic hedgehog can trigger hair growth Mayumi Ito, badociate professor at NYU.
Hair regrowth on damaged skin is an unmet need Heo said, because of the disfigurement suffered by thousands of people affected by trauma, burns and the like.
However, her immediate goal, she said, is to ensure that mature skin regains its embryonic state to grow new hair follicles, not only on injured skin, but also on people who have become bald.
Ito said scientists have so far badumed that, as part of the healing process, scarring and collagen build-up in the damaged skin was responsible for her inability to regrow hair. [19] 659003] "We now know that this is a problem signal in cells that are very active as we grow in the uterus, but less in mature skin cells with age," she said.
One of the key findings of the study is that no evidence of hair growth was observed on untreated skin, but was observed in the treated skin, providing evidence that sonic signaling by the hedgehog was behind hair growth, the researchers explained.
To circumvent the risk of tumors reported in other experiments having focused on the sonic hedgehog pathway, the team only turned on the localized fibroblasts.
Researchers have also targeted fibroblasts because cells are known to help direct some of the biological processes involved in wound healing.
Hair regrowth was observed in the cells. four weeks after the skin injury in all treated mice, the structure of the root and stem of the hair beginning to appear after nine weeks.
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