[ad_1]
US researchers have pushed locks of hair on damaged skin by waving crosstalk among the skin cells that form the roots of the hair, which could help search for better drugs to restore hair growth.
The New York University (NYU) team examined the effect of different signaling pathways on the damaged skin of laboratory mice as well as on cells called fibroblasts that secrete collagen – the structural protein responsible for maintaining the shape and strength of the skin and hair.
The researchers then activated the sonic signaling pathway of the hedgehog used by the cells to communicate with each other.
It is also known that this pathway is very active during the early stages of human growth in the uterus, when hair follicles form, but is otherwise stuck in the injured skin in the adult in good condition. health.
The researchers reported that hair regrowth was observed four weeks after the skin injury, and that the structure of the hair root and stem began to appear after nine weeks.
"Our results show that stimulating fibroblasts by the sonic hedgehog pathway can trigger hair growth never seen in scarring," said Mayumi Ito, badociate professor and cell biologist at NYU Langone Health.
Until now, it was badumed that in the process of scarring, scars and collagen build up in damaged skin were behind his inability to regrow hair.
"We now know that it is a signaling problem in cells that are very active while we grow in the uterus, but less in mature skin cells with age" , Ito noted.
The study was published in the journal Nature Communications.
According to Ito, hair regrowth on damaged skin is an unmet need in medicine because of the disfigurement of thousands of people with trauma, burns and other injuries.
However, she adds, her most immediate goal is to tell mature skin to return to their embryonic state to allow the growth of new hair follicles, not only on injured skin, but also on bald people aging.
– IANS
RT / MAG / SED
(This story was not edited by Business Standard staff and is generated automatically from a syndicated feed.)
[ad_2]
Source link
