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Researchers say a new polio vaccine that does not require refrigeration could one day be used around the world to defeat the contagious disease that mainly affects children under five.
Researchers at the University of Southern California (USC) are lyophilized to powder and can be stored at room temperature for four weeks and then rehydrated.
Tested on mice, the new vaccine offered total protection against
"Stabilization is not a basic science, so most academics do not pay much attention to this area ", said senior author Woo-Jin Shin, of the USC's Keck School of Medicine.
"However wonderful drugs and vaccines are, if they are not stable enough to be transported, it does not do any good to anyone," Shin added. The study appears in the journal mBio.
of. Since then, researchers have created thermostable vaccines against measles, typhoid and meningococcal disease. Scientists, however, have not been able to make a polio vaccine that retains its effectiveness through lyophilization and rehydration.
Shin and his colleagues used two laboratory techniques – liquid chromatography and high throughput screening – allowing them to badyze a large volume of particles. ingredients and formulations until they find one that has worked.
They now hope that a foundation or company will take over the project to fund human studies and commercialize the injectable vaccine.
Polio is about to disappear. eradication, with only 22 cases reported worldwide in 2017. The highly contagious disease, which causes lifelong paralysis and disability, mainly in young children, is a memory that erases in many places. Yet, in countries where immunization rates are erratic, young children are at risk.
The main obstacle to complete eradication is the creation of a stable temperature vaccine that can be used in developing countries where refrigeration may not be available. Recent cases of poliomyelitis have been reported in Nigeria, Papua New Guinea, Syria and Pakistan. (IANS)
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