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Researchers have reconstructed locks of hair on damaged skin by shaking the cracks between the skin cells that form the hair roots.
Results of New York University (NYU) Medical School Researchers. better explain why hair does not grow normally on injured skin.
The study, published in the journal Nature Communications, could help in the search for better drugs to restore hair growth.
She examined the effect of different signaling pathways in damaged skin from laboratory mice.
Experiments were conducted on cells called fibroblasts that secrete collagen, the structural protein most responsible for maintaining the shape and strength of skin and hair.
The researchers activated the sonic signaling pathway of the hedgehog used by cells to communicate.
It is known that this pathway is very active during the early stages of human growth in the uterus, when hair follicles form, but is otherwise The researchers explained that this may explain why hair follicles do not grow not in the replaced skin after an injury or surgery.
Our results show that stimulation of fibroblasts by the sonic hedgehog can trigger the growth of hair Mayumi Ito, badociate professor at NYU.
Hair regrowth on damaged skin is an unmet need in medicine, said Ito, because of the disfigurement suffered by thousands of people affected by trauma, burns and other injuries.
However, her more immediate goal, she said, is to ensure that mature skin returns to its embryonic state, so that it can grow new hair follicles, not just on the skin. injured skin, but also on people who have become bald.
Ito stated that scientists have so far hypothesized that, as part of the healing process, scarring and collagen build-up in damaged skin was responsible for his inability to regrow hair.
"We now know that this is a signaling issue in cells that are very active as we develop in the uterus, but less so in mature skin cells. with age, "she said.
One of the key findings of the study was that no signs of hair growth had been observed in untreated skin, but were observed in the treated skin, providing evidence that sonic signaling by the hedgehog was behind hair growth, explained the researchers.
To circumvent the risk of tumors reported in d & # 39; 39, other experiments having focused on the sonic hedgehog path, the team only turned on the localized fibroblasts.
The researchers also targeted the fibroblasts because the cells are known to help direct some of the biological processes involved in the cicat
Hair regrowth was observed in the cells. Four weeks after cutaneous injury in all treated mice, the structures of the root and stem of the hair beginning to appear after nine weeks.
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