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BALTIMORE, June 18, 2019 / PRNewswire / – Dr. Leslie C. Costello, University of Maryland Medical Center Scientist George W. Yu, M.D (George Washington University, D.C.), who was the urologist for managing a patient who presented with terminal "androgen-independent" prostate cancer. The patient had been diagnosed with "androgen-dependent" advanced prostate cancer, which included lymph node metastasis. He received hormonal androgen-ablation therapy, along with chemotherapy and radiation therapy, which attenuates the progressing malignancy and extends the life of the patient. However, the treatment leads to the development and progression of "androgen-independent" malignancy, which is a terminal prostate cancer. With this condition, the patient had an expected survival of 2-3 years. Since the cause of this malignancy had been unknown, an effective treatment did not exist.
Dr. Costello and his colleague, Dr. Renty B. Franklin, have been involved in prostate cancer research since 1975, which led to their recent concept that the hormone prolactin initiates the development and progression of androgen-independent malignancy. That information provided for the development of an effective chemotherapy for terminal, advanced prostate cancer requires the removal of prolactin levels in the blood. After seven weeks of their treatment, the patient's plasma prolactin concentration decreased 88%, and he no longer exhibited prostate gland malignancy and metastasis. His circulating tumor cell count was 5.4, which indicates an expected survival of about 21 months. Following treatment, the count equaled zero. This may be the first report of a patient who has successfully completed androgen-independent advanced prostate cancer.
Prostate cancer accounts for about 165,000 cases / year, with 25,000 deaths / year in the US and 1.1 million cases / year with 260,000 deaths / year worldwide. Most of the deaths are due to androgen-independent advanced prostate cancer.
Dr. Costello adds that it will be important to determine whether they will be effective in other patients with terminal, advanced prostate cancer.
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Dr. George W. Yu is the Clinical Professor in the Department of Urology; George Washington University School of Medicine; Washington, D.C. 20037 USA.
Dr. Costello and Dr. Franklin are Professors in the Department of Oncology and Diagnostic Sciences at the University of Maryland School of Dentistry and in the University of Maryland Greenebaum Comprehensive Cancer Center in Baltimore, Maryland.
Dr. Costello and Dr. Franklin are among the world's top 5% of biomedical scientists.
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This patient has been published and is available at:
http://www.mathewsopenaccess.com/case-reports-articlesinpress.html.
This Announcement was prepared on 06/04/2019 by:
Professor Leslie C Costello
[email protected].
Note: email responses will be accepted only from clinicians and not from other individuals.
SOURCE University of Maryland Medical Center
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