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The road to the human artificial ovary was opened. For the first time the structures surrounding immature oocytes were isolated and cultured on a scaffold of ovarian tissue deprived of its cells, until they could function
Research for combat infertility [19659003"It'saproofofprincipleforpreservingthefertilityofwomenwhohavetodealwithatreatmentthatcouldcompromiseit"saidSusannePorsresearchcoordinatorattheReproductiveBiologyLaboratoryofCopenhagen'sRigshospitaletTheresultwaspresentedatthecongressoftheEuropeanSocietyofHumanReproductionandEmbryology(Eshre)underwayinBarcelonaThegoalistoenablewomenfacingcancertreatmenttomaintainfertilitysafely
Reducing Risks for Women
Currently, ovarian tissues are stored before treatment and frozen to be replanted and the research group Pors is one of the pioneers in this field, with ovarian tissue of 1100 patients preserved over the last 20 years, including 115 defrosted and transplanted in 90 women. However, Pors noted, "removing cells from frozen ovarian tissue and transferring vital follicles to it could avoid the risk of reintroducing potentially present malignant cells into the original tissue."
The Next Steps
The experiments were done with ovarian tissue taken by women who had wanted to keep it before facing an anticancer therapy. The first step was to remove the cells present in the tissue by means of a chemical process of three days. This gives a sort of scaffold in which the follicles are replanted. "We saw that follicles were able to repopulate cells with tissue," said Pors referring to experiments performed in test tubes, and then the artificial ovary thus obtained was transferred to a mouse, demonstrating Egg growth, with a very low risk of malignant cell transfer. "The next step – said the researcher – will be to understand how the ovary developed with this technique develops, with periods of observation. up to 6 months. "As for the first human tests," will still take many, many years. "
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