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Clinical research carried out in recent years confirms the remarkable anti-inflammatory and anti-inflammatory and antioxidant properties of curcumin. In addition, a potential neuroprotective effect of curcumin itself has also recently been demonstrated
Curcumin, therefore. It appears to influence the modulation of the inflammatory state that underlies obesity, diabetes, cardiovascular disorders, and tumors
by X-ray crystallography and the specificity of the disease. Inhibitor of the kinase, researchers at the University of California San Diego School of Medicine, in collaboration with researchers from Peking University and Zhejiang, reveal that curcumin, a chemical compound naturally present in the spice, binds to the enzyme kinase kinase 2 regulated by the double tyrosine (DYRK2) At the atomic level
This unprecedented biochemical interaction of curcumin leads to l? DYRK2 inhibition that hinders cell proliferation and reduces the burden of cancer. But before turning to curcumin or turmeric supplements, Sourav Banerjee, PhD, a postdoctoral researcher at the University of San Diego School of Medicine, warns that curcumin alone can not be the reply. "In general, curcumin is expelled from the body rather quickly," Banerjee explained. "Because curcumin is an effective medicine, it must be modified to enter the bloodstream and remain in the body long enough to reach cancer.
Due to various chemical problems, curcumin alone may not be sufficient to completely reverse cancer in human patients. "Writing in the July 9 issue of the Proceedings of the National Academy of Sciences, Banerjee and colleagues report that curcumin binds and inhibits DYRK2 leading to prevention proteasome – the mechanism of cellular proteins that destroy unnecessary or damaged proteins in cells – which in turn reduces cancer in mice. "Although curcumin has been studied for over 250 years and its anticancer properties have been reported previously, no other group has reported a co-crystalline structure of curcumin bound to a protein kinase target" , said Banerjee, first author of the study. "
Through their work on crystallography, our Peking University collaborators, Chenggong Ji and Junyu Xiao, helped us visualize the interaction between curcumin and DYRK2." "IKK and GSK3 kinase enzymes were considered the main targets of curcumin leading to the anticancer effect, but the co-crystalline structure of curcumin with DYRK2 badociated with an inhibitory profile of 140 kinases reveals that curcumin binds strongly at the active site DYRK2, inhibiting at a level 500 times more potent than IKK or GSK3
"Working alongside Jack E. Dixon, Ph.D., professor emeritus of pharmacology, cellular and molecular medicine , chemistry and biochemistry at the University of San Diego, Banerjee and the team are looking for proteasome regulators to inhibit the formation of tumors from proteasome-dependent tumors such as triple-negative bad cancer ( TNBC) and sma neoplasm called multiple myeloma. Using biochemical models, mouse cancer models and cell models, the team discovered that curcumin is a selective inhibitor of DYRK2 and that this new molecular target has promising antitumor potential not only for chemosensitive tumors but also for proteasome inhibitors
"Our results reveal an unexpected role of curcumin in inhibiting the proteasome DYRK2 and provide evidence that pharmacological manipulation of proteasome regulators may offer new opportunities for the treatment of Triple negative bad cancer and difficult to treat multiple myeloma, "said Dixon, who co-authored with Xing Guo of Zhejiang University, PhD, on paper. "Our main goal is to develop a chemical that can affect DYRK2 in patients with these tumors."
Depletion of DYRK2 alters the activity of the proteasome and shows a slowing of cancer proliferation and dramatically reduces tumor burden in mouse models. In combination with carfilzomib, the FDA-approved multiple myeloma drug, curcumin induces much higher cell death, while normal non-cancer cells are less affected. This suggests that targeting proteasome regulators (such as DYRK2) in combination with proteasome inhibitors might be a promising approach to antitumor therapy with fewer side effects, but additional work is needed, Banerjee said.
Turmeric contains hundreds of components including potbadium, vitamin C, starch equal to 26%, in addition to essential oils and bitter oils that are able respectively to stimulate appetite and training digestive enzymes, but the one that has attracted the most attention of "Curcumin" and especially its particular antitumor and antioxidant, detoxifying and anti-inflammatory nature
Finally, on the tumors chapter, turmeric could have a positive effect given the cancer's close connection with altered inflammatory status and oxidative stress and given the potential antioxidant and anti-inflammatory properties of this spice. It is also believed that turmeric contributes to slowing the growth of tumors. The locals are interesting and encourage further research on turmeric and other spices.
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