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Additional oxygen intake significantly reduces morning blood pressure in patients with obstructive sleep apnea (OSA). This is what emerges from a crossover study published by Respiratory and Critical Care Medicine
26 JUL – (Reuters Health) – Osa is badociated with high blood pressure during the day and It has been shown that mechanical ventilation in continuous positive airway pressure (CPAP) improves this parameter, especially in patients with resistant hypertension. However, it is not known whether CPAP works by eliminating intermittent hypoxia or reducing revivals
Study
Chris D. Turnbull and colleagues at the Oxford Center for Respiratory Medicine at Churchill Hospital in the UK sought to understand the role of intermittent hypoxia in increasing daytime pressure in Osa by testing 25 people with moderate to severe Osa who had been treated by PPC for at least one year.
Patients were randomized during the first visit to receive oxygen or additional air at night at a level of 5l / min via nasal cannula or face mask, replacing their treatment. Cpap for two weeks. After a two week period with their CPAP, the patients returned again to receive additional air or oxygen administration for two weeks, always in place of their treatment.
Results
Compared to air, additional oxygen stopped the pressure increase, with a relative decrease of 6.6 mmHg from the systolic and 4.6 mmHg diastolic pressure. Oxygen supplementation has not had any significant effects at home or in the office on the morning heart rate. While the exact mechanisms that lower blood pressure to increase oxygen during Cpap deficiency, hypoxia remains unclear. Intermittent seems to be the main cause of pressure increase in OSA – the researchers explain – It was a mechanistic physiological study and further research is needed to understand if the patient is in the same position. Additional oxygen intake can result in a clinical benefit. "
Source: Respir Crit Care Med 2018
Reuters Staff
(Quotidiano Sanità / Popular Science)
] July 26, 2018
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