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A new vaccine he could probably end the gluten-free diets soon. In fact, many people are forced to give up so many delicacies because of an aggravated illness through the consumption of gluten-containing foods. But thanks to the new drug, all this could be only a sad memory. The drug is still being tested but seems to have achieved more than satisfactory results. Here is what it is.
Goodbye gluten-free foods
A study by Australian scientists showed how a potential vaccine could significantly improve the quality of life for all patients with celiac disease. The immunotherapeutic drug is administered by injection to reprogram the abnormal response of the immune system to gluten. In fact, when a person is suffering from celiac disease, damage to the intestine is evident when eating gluten-rich foods. This can cause serious damage to the body that, among other things, can not properly absorb the nutrients.
At the moment there are no treatments
Up & # 39; to yesterday medicine has always failed in the treatment of celiac disease; in fact, the only option available is to eliminate gluten-free foods from the diet, but there is no effective treatment. On the other hand, the new vaccine is the first truly viable solution. According to gastroenterologist Jason Tye-Din of the Royal Melbourne Hospital, this drug targets specific gluten cells. At Herald Sun, Tye-Din explained that the vaccine taught the body how to handle gluten so that it does not attack the intestine.
The professor of the immune system
"If you can administer the vaccine in subsequent injections, you can re-educate your immune system in order to learn how to develop tolerance.This study is important to establish a clinical demonstration of a treatment that offers benefits. Other than the gluten-free diet, if the process is positive, people could aim for a normal diet, which is the last hope we have. "
L & # 39; study
Vaccine trials are continuing and the Tye-Din team is recruiting another 150 patients in Australia, New Zealand and the United States. All participants will receive an injection or placebo. According to Sarah Sleet, CEO of Celiac UK, it can be considered an "important step" in the search for a vaccine against celiac disease.
NexVax
The new vaccine is called Nexvax2 ® and is currently the only therapeutic approach to celiac disease. Its potential is to enable patients to regain a normal diet, good health and a better quality of life. It is a combination of three peptides that elicit an immune response in patients with celiac disease and carriers of the HLA-DQ2.5 gene (available in 80 to 90% of patients). The injection takes place intradermally and aims to reprogram T cells that respond to gluten antigens so that they stop responding defensively by activating a pro-inflammatory response. As a result, T cells stop causing inflammation of the small intestine and the damaged tissue heals. Vaccination boosters would stabilize gluten tolerance. The drug fact sheet is available on the Immusant website.
Excellent tolerance
"A total of four Phase 1 studies have shown that NexVax 2 is well tolerated, and the vaccine will initially be tested in combination with a gluten-free diet to protect people from accidental exposure to gluten, and not as a complete replacement for the diet. gluten-free, even if this is the ultimate goal, progress in the treatment of celiac disease is exciting and promising, but treatment will last several years, "concludes Sleet.
Scientific sources
[1] Celiac disease – Immuante [2] Study of the Safety, Effectiveness and Tolerability of Nexvax-2 in Patients with Celiac Disease – Clinical Trial [3] ImmusanT Announces Completion of Nexvax2® Phase 1b Clinical Trial for the Treatment of Celiac Disease [4] Programs for Celiac Disease Nexvax2®TherapySource link
