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Commonly used pills to lower blood pressure, such as ramipril, could increase the risk of lung cancer by up to 14%
The so-called inhibitors of ace, if they are taken for a long time, could have a serious effect on lung cancer. A risk that 14% could go up to 31% if these drugs are used for 10 years.
This is evident from a study by the Department of Epidemiology, Biostatistics and Occupational Health at McGill University, Montreal, Canada, which, in collaboration with the Jewish General Hospital and the University of Toronto, discovered dangerous badociation between lung cancer and anti-as ("Ace" means "angiotensin converting enzyme", to indicate the angiotensin converting enzyme inhibitors). But cause-and-effect relationships have yet to be demonstrated.
In a magnifying glbad, the most commonly prescribed antihypertensive drugs to control blood pressure, such as ramipril, which in 2017 was prescribed only 27 million times in the United Kingdom, while there are approximately 163 million prescriptions in the United States each year.
L & # 39; study
The researchers performed a statistical badysis of data from nearly one million Britons all treated with inhibitors from January 1, 1995 to December 31, 2015. All were over 18 years of age and n & # 39; 39, had no history of cancer behind.
During the follow-up period, doctors diagnosed 8,000 cases of lung cancer and, by correcting all the data and isolating the risk factors normally badociated with this type of tumor, Laurent Azoulay, coordinator of the lung cancer, said: study, found that they were badociated with an increased risk of lung cancer by 14% compared to other hypotensive drugs. In patients taking ACE inhibitors for a decade, the risk increase was even 31%.
The reason is that it is the inhibitors of the ace that promote the accumulation of chemicals in lung tissue, such as bradykinin – badociated with the development of lung cancer.
Is there really something to worry about then? The researchers are cautious, which highlights in any case that this is a simple observational study that has not shown any cause-and-effect relationship between drugs and cancer. In addition, they observe that the benefits in terms of survival from the use of ACE inhibitors are always greater than a possible risk of lung cancer for a given patient. Therefore, if the doctor prescribes them, they must be taken safely.
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