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Sensitivity to coffee: There are those who can drink 5 cups a day without major problems and those who spend the night in white to drink only one. The way individuals metabolize caffeine also depends on the genetic makeup, so that it is possible to divide coffee consumers into three groups: high, medium and low sensitivity to coffee.
So there is no recommended dose can be good for everyone, but we must first check what kind of compatibility there is with coffee.
This is apparent from the report of Dr. JWLanger professor of pharmacology at the Faculty of Medicine of the University of Copenhagen. , produced for the Institute for Scientific Information on Coffee (ISIC).
The report " Genetics, Metabolism and Individual Responses to Caffeine " is based on evidence from existing literature to badyze and explain why are more sensitive to the effect of caffeine and how health care professionals should consider these features when advising patients.
The prevention of caffeine is probably determined by two main genetic factors: the greater or lesser rapidity of hepatic metabolism -3. and the presence of a genetic variation that makes the central nervous system more sensitive to the stimulating effects of caffeine. 1,4-8
In view of these factors, Dr. Langer proposed three descriptive levels of overall sensitivity to caffeine:
High sensitivity to caffeine
- Metabolism slow liver and strong binding to the central nervous system. Even small amounts of caffeine cause a stimulating effect and higher doses can cause sleep problems, as happens in a minority of people.
Smooth sensitivity to caffeine
- The balance between inactivation of caffeine in the liver and binding in the central nervous system means that the individual can usually drink 2-5 cups of coffee during the day, without contraindications or sleep disorders. Usually, caffeine is not recommended at night, but individual differences prevail, as happens with most people.
Low sensitivity to caffeine
- Rapid metabolism of caffeine. Larger amounts can be consumed (although health professionals recommend not exceeding five cups of coffee per day as part of EFSA9 guidelines). The coffee you drink before bedtime does not normally disturb sleep.
Dr. Langer explains: " We all drink different coffee: our programs of genetic makeup react to caffeine, so like the color of hair and eyes ."
An individual with low sensitivity caffeine will probably not feel the effects typically obtained from this substance, such as awakening, alertness and increased concentration. It is important for health experts to point out that those who metabolize caffeine quickly should not exceed the recommended daily dose to try to achieve the desired effects.
Dr. Langer continues: " Most people self-regulate caffeine intake, based on personal experience and individual tolerance. However, it is important that people with low caffeine sensitivity stay in the recommended daily dose of caffeine up to 400 mg of caffeine, which equates to about five cups of coffee at most . "
in addition to explaining the genetic variations that influence individuals' reactions to caffeine, he points out that such reactions may also be determined by non-genetic factors such as smoking habits, pregnancy and the The report points out that, when they are explicitly asked about caffeine consumption, health professionals must also take into account the individual responses of patients.
] Coffee and Health
- First, remember that in 2016, the World Health Organization removed coffee from the list of possible carcinogens for humans and ] a significant number of scientific studies suggests moderate consumption of coffee, 3-5 cups a day, is not badociated with increased risk of cancer and is rather protective of a series of diseases such that in addition to u Type 2 Diabetes, Liver and Endometrial Cancer
- Recent research published in Annals of Internal Medicine 3,4 showed an badociation between coffee consumption, also decaffeinated, and a lower risk of death from heart disease, cancer, heart attack, diabetes, respiratory and kidney disease .
- There is ample evidence that moderate coffee consumption can reduce the risk of developing Alzheimer's disease by up to 27% 5 [19659021] Moderate coffee consumption , equivalent to about 3 to 5 cups, is healthful in the adult population, is part of a healthy and balanced diet and an active lifestyle also recognized by the opinion of the EFSA (European Food Safety Authority) 2015 on caffeine consumption 6 .
- In conclusion, a large scientific literature reports the many benefits badociated with moderate coffee consumption on other important aspects of human physiology, from memory to concentration, from physical performance to slowing cognitive decline. Age-related physiological, reduced risk of neurodegenerative diseases (such as Alzheimer's disease and Parkinson's disease) to a strong preventive and protective action against type 2 diabetes and certain liver diseases including cirrhosis, steatosis and hepatitis.
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