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An autotransplantation of pancreatic islets in the liver of was successfully performed by a 19-year veteran of a severe motorcycle accident . This is the first case in Italy, made possible by the collaboration between Spedali Civili di Brescia and San Raffaele Hospital in Milan . The young man had reported a laceration that required the removal of the pancreas, where most cells responsible for the production of insulin were found
Milan-Brescia, first case in Italy of autotransplantation of pancreatic islets in the liver
] The San Raffaele hospital team
The team of Spedali Civili
The intervention is the first case of autotransplantation of the pancreatic islands with remote isolation and was performed by the team of the III Division of Surgery of Spedali C ivili, directed by Guido Alberto Mbadimo Tiberio and the group of the pancreatic islands of ICRC Ospedale San Raffaele, led by Professor Lorenzo Piemonti .
Isolation of insulin-producing cells – In a case like that occurred at the age of 19, the risk of developing diabetes shortly after operation is 10-20%. In the long run, however, the percentage reaches up to 50%, which radically affects the quality of life of the patient. To avoid this risk, doctors removed part of the organ and worked all night to isolate and purify the beta cells used for insulin production. The next day, Professor Piemonti transferred the cells to Brescia to reinfect them in the liver of the patient
Reintegration in the liver – Once released into the liver by the portal vein, the beta cells take root within a few weeks and Resume the production of insulin, avoiding the risk of developing diabetes. Three weeks after the serious accident, the patient was released in excellent general conditions. In particular, the glycemic profile, altered after pancreatectomy, has progressively improved, up to absolute normality values within 24 hours. The young people will be followed in the coming months to check the regularity of the post-operative and the effectiveness of reconstituted pancreatic endocrine.
A Unique Case – "Up to now, fewer than ten cases have been described worldwide where this approach has been used, which requires skills that can only be coordinated urgently in some situations, as well as the removal of the pancreas with a minimally invasive technique and the preparation of tissue for transplantation in a different place from that of hospitalization.they constitute a unique combination, which is not never produced in any of the cases described so far, explained Professor Piemonti
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