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WASHINGTON (Reuters) – US scientists have come up with an unprecedented new way to restore memories lost because of Alzheimer's disease, believing that what they've discovered happens for the first time in the world. world.
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Researchers at the University of Buffalo, USA, and published their study in the journal Fit the Curent, have come up with a new mechanism that could reflect the memory loss suffered by patients with the disease of Alzheimer's focusing on genetic modifications resulting from the effects of DNA sequences, called "epigenetic".
"We not only identified the genetics that contributes to memory loss, we found a way to temporarily reverse it in an animal model," said Chen Yan, a professor at the university.
"The Alzheimer's disease is mainly due to the fact that patients are unable to retain the information, which has been learned recently and more evidence of a cognitive decline, due to the loss of glutamate receptors, that are essential to learning and short-term memory, "Jan said.
The researchers found that the loss of glutamate receptors was the result of a genetic process called "repressive modification of the histone", very high in patients with Alzheimer's disease.
In this study, researchers were able to correct the cognitive impairment of patients with Alzheimer's disease by targeting lignin enzymes, which restore glutamate receptors, by injecting three times patients with the disease. Alzheimer's compounds designed to inhibit the inhibition of the repressive modification of the histone, in order to restore cognitive functions, spatial memory and memory. Operating.
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