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A new study has shown that Gina, badociated with Alzheimer's disease, affects cognitive health much earlier than expected, suggesting that the disease may begin in childhood.
The APOE gene, known as the "dementia gene", has long been badociated with Alzheimer's disease. This gene produces a protein called "lipid core" (E), which contains 3 copies or alleles, which represents about 15% of the population.
Although Alzheimer's disease is an age-related disease, a new study found that children younger than 7 years old with e4 variation had poor intelligence test scores.
US researchers have pointed out that this shows that "the adverse effects of e4, manifested in adulthood", have resulted in the emergence of a cognitive decline.
The research was conducted by the University of California at Riverside, led by Professor of Psychology, Ms. Chandra Reynolds.
According to the Alzheimer's Association, the APOE gene has "the best-known effect of any gene affecting late Alzheimer's disease" and comes in the form of three copies: e2, e3, and e4.
Each person has two copies of the gene, such as e2 / e3, e2 / e4, etc., but a quarter of the world's population has a copy of the e4 gene, which is more than twice as likely to cause disease. ; Alzheimer's.
There is about 2% of the population, they receive a "double dose", while inheriting the e4 version of both parents, it increases the risk between 3 and 5 times.
Little is known about the effects of APOE on early brain health, which prompted researchers to badyze gene differences in 1,321 participants in a behavioral development study throughout their lives. life in twins and cohorts of Colorado.
The results showed that children and adolescents who took the e4 version of the APOE gene had the worst IQ scores at 1.91 points.
The researchers point out that this slight decrease in IQ can have a significant impact on a person's cognitive health in the future life.
In addition, those who received a "double dose" of e4 gave less test results than those who had only one variable of this protein and the participants were the most harmful.
"Our results suggest that the e4 adverse effects of the APOE gene are evident before puberty, especially in women," the researchers wrote.
The researchers hope that their discoveries will lead to additional research that can prevent cognitive decline.
Source: Daily Mail
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