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Scientists at the Max Planck Institute of Experimental Medicine in the German city of Göttingen have identified a protein that disrupts the elimination of anxiety during experiments on rats. Anxiety disorders are badociated with the activity of tonsil neurons and anti-anxiety medications, such as benzo-diazepines, help reduce this activity by enhancing the function of "inhibiting tongs", but side effects have been recorded. In the latest issue of Nature Communications.
"Clamps" are usually links between the nerve cells of the brain, in which the information is transferred from one neuron to another, and between these links, there is what is called inhibitory neurotransmitters, which prevent the region of the "tonsillar brain" from transmitting stimuli that cause fear and anxiety, Benzodiazepines promote this inhibitory effect, but unfortunately they not only affect the inhibitory ligaments, but also many other inhibitory entanglements in the brain, resulting in major side effects such as a reduction in concentration, prompting scientists to seek new targets. Specifically anti-anxiety.
The study was designed to discourage the production of the recently discovered IgSF9b protein in experimental mice, which has been shown to produce a protein bridge at inhibitory synapses between two neighboring neurons, thereby helping to promote anxiety. inhibiting its production preventing the transmission of this sensation between cells.
"We had two sets of test rats that were released in an empty test room, the first one was an expression of anxiety," said Olga Babaev, who conducted the experiments as part of her PhD work. in a report published by the Max Planck Institute. One of the corners of the room was removed, while the other moved freely between the corners of the room without fear and, when we inhibited the production of IgSF9b proteins, the anxious animals again freely walk around the room.
"This result prompts us to look in the future for a protein target for the treatment of anxiety disorders, to avoid the side effects of current medications."
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